LitCovid-sentences  

PubMed:33161369 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Longitudinal characterization of the IgM and IgG humoral response in symptomatic COVID-19 patients using the Abbott Architect.
T2 127-138 Sentence denotes BACKGROUND:
T3 139-273 Sentence denotes Antibody testing has recently emerged as an option to assist with determining exposure to SARS-CoV-2, the causative agent of COVID-19.
T4 274-426 Sentence denotes Elucidation of the kinetics and duration of the humoral response is important for clinical management and interpreting results from serological surveys.
T5 427-438 Sentence denotes OBJECTIVES:
T6 439-618 Sentence denotes Here we evaluated the clinical performance of Abbott SARS-CoV-2 IgM and IgG assays, as well as the longitudinal dynamics of the antibody response in symptomatic COVID-19 patients.
T7 619-644 Sentence denotes STUDY DESIGN AND RESULTS:
T8 645-749 Sentence denotes The diagnostic specificity was 100 % for IgM and 99.67 % for IgG using 300 pre-COVID-19 serum specimens.
T9 750-1034 Sentence denotes Using 1349 sequential serum samples collected up to 168 days post symptom onset from 427 PCR-confirmed individuals, clinical test sensitivity of the SARS-CoV-2 IgM assay was 24.6 % at ≤7 days, 75.3 % at 8-14 days, 95.0 % at 15-21 days, and 96.0 % at 4-5 weeks (peak test sensitivity).
T10 1035-1098 Sentence denotes The median duration of time for IgM seroconversion was 10 days.
T11 1099-1212 Sentence denotes IgM levels declined steadily 4-5 weeks after symptom onset, and the positive rate dropped to 30.8 % at >3 months.
T12 1213-1402 Sentence denotes The diagnostic sensitivity for the SARS-CoV-2 IgG assay post symptom onset was 23.2 % at ≤7 days, 69.5 % at 8-14 days, 93.6 % at 15-21 days, and 99.6 % at 4-5 weeks (peak test sensitivity).
T13 1403-1468 Sentence denotes The median duration of time for IgG seroconversion was 11.5 days.
T14 1469-1601 Sentence denotes During the convalescent phase of the infection, a decline in the IgG level was observed in patients who were followed for >100 days.
T15 1602-1710 Sentence denotes Despite that decline, 92.3 % of the patient cohort remained IgG positive 3-6 months following symptom onset.
T16 1711-1723 Sentence denotes CONCLUSIONS:
T17 1724-1907 Sentence denotes This study demonstrates the Abbott IgM assay against SARS-CoV-2 is detected slightly earlier compared to IgG, with both tests exhibiting excellent overall sensitivity and specificity.
T18 1908-2064 Sentence denotes In symptomatic patients who test negative by PCR for a SARS-CoV-2 infection, assessing IgM and IgG antibodies can aid in supporting a diagnosis of COVID-19.