Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-68 |
Sentence |
denotes |
Neuroimaging findings of brain MRI and CT in patients with COVID-19: |
T2 |
69-107 |
Sentence |
denotes |
A systematic review and meta-analysis. |
T3 |
108-116 |
Sentence |
denotes |
PURPOSE: |
T4 |
117-262 |
Sentence |
denotes |
To comprehensively evaluate the incidences of abnormal neuroimaging findings in patients with COVID-19 via a systematic review and meta-analysis. |
T5 |
263-270 |
Sentence |
denotes |
METHOD: |
T6 |
271-449 |
Sentence |
denotes |
PubMed-MEDLINE and EMBASE were searched for original articles reporting imaging findings of the brain in adult patients with COVID-19 between January 1, 2020 and October 9, 2020. |
T7 |
450-656 |
Sentence |
denotes |
Abnormal neuroimaging findings were categorized as (1) cerebral microhemorrhages, (2) acute spontaneous intracranial hemorrhage (ICH), (3) acute to subacute infarcts, and (4) encephalitis or encephalopathy. |
T8 |
657-744 |
Sentence |
denotes |
Pooled incidences of neuroimaging findings were assessed using random-effects modeling. |
T9 |
745-865 |
Sentence |
denotes |
Between-study heterogeneity was explored by using the χ2 statistic for pooled incidences and the inconsistency index I2. |
T10 |
866-972 |
Sentence |
denotes |
The quality of the studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies. |
T11 |
973-1068 |
Sentence |
denotes |
Subgroup meta-regression analysis was performed to identify potential sources of heterogeneity. |
T12 |
1069-1077 |
Sentence |
denotes |
RESULTS: |
T13 |
1078-1147 |
Sentence |
denotes |
Twenty-one eligible papers, including 2125 patients, were identified. |
T14 |
1148-1447 |
Sentence |
denotes |
The pooled incidences of cerebral microhemorrhages, acute spontaneous ICH, acute/subacute infarcts, and encephalitis/encephalopathy were 6.9 % (95 % confidence interval [CI], 4.9 %-8.9 %), 5.4 % (95 % CI, 3.1 %-7.6 %), 24.0 % (95 % CI, 16.1 %-31.8 %), and 3.3 % (95 % CI, 1.9 %-4.7 %), respectively. |
T15 |
1448-1534 |
Sentence |
denotes |
Substantial heterogeneities were noted for all neuroimaging findings (I2 = 87 %-97 %). |
T16 |
1535-1604 |
Sentence |
denotes |
Significant publication biases were present in the pooled incidences. |
T17 |
1605-1777 |
Sentence |
denotes |
In the subgroup meta-regression analysis, patients with mean or median ages over 65 years showed a significantly lower incidence of encephalitis/encephalopathy (P < 0.001). |
T18 |
1778-1950 |
Sentence |
denotes |
Furthermore, studies reported that patients in ICU had significantly higher incidences of cerebral microhemorrhages (P < 0.001) and encephalitis/encephalopathy (P < 0.001). |
T19 |
1951-1963 |
Sentence |
denotes |
CONCLUSIONS: |
T20 |
1964-2067 |
Sentence |
denotes |
Considerable incidences of abnormal neuroimaging findings have been reported in patients with COVID-19. |
T21 |
2068-2150 |
Sentence |
denotes |
Acute to subacute cerebral infarction was the most prevalent neuroimaging finding. |