LitCovid-sentences  

PubMed:33144323 JSONTXT 51 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Adaptation of Influenza Viruses to Human Airway Receptors.
T2 59-228 Sentence denotes Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease.
T3 229-394 Sentence denotes Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses.
T4 395-584 Sentence denotes IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential.
T5 585-781 Sentence denotes One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells.
T6 782-991 Sentence denotes HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal).
T7 992-1168 Sentence denotes In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors.
T8 1169-1352 Sentence denotes Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic.
T9 1353-1536 Sentence denotes This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources.
T10 1537-1822 Sentence denotes In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.