Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-40 |
Sentence |
denotes |
The Impact of COVID-19 on Blood Glucose: |
T2 |
41-79 |
Sentence |
denotes |
A Systematic Review and Meta-Analysis. |
T3 |
80-91 |
Sentence |
denotes |
Background: |
T4 |
92-293 |
Sentence |
denotes |
Diabetes mellitus is considered a common comorbidity of COVID-19, which has a wide spectrum of clinical manifestations ranging from asymptomatic infection to severe respiratory symptoms and even death. |
T5 |
294-373 |
Sentence |
denotes |
However, the impact of COVID-19 on blood glucose has not been fully understood. |
T6 |
374-499 |
Sentence |
denotes |
This meta-analysis aimed to summarize available data on the association between glycemic parameters and severity of COVID-19. |
T7 |
500-508 |
Sentence |
denotes |
Methods: |
T8 |
509-598 |
Sentence |
denotes |
PubMed, EMBASE, and Cochrane Library were searched from December 1, 2019 to May 15, 2020. |
T9 |
599-752 |
Sentence |
denotes |
Observational studies investigating blood glucose or glycated hemoglobin A1c (HbA1c) according to the severity of COVID-19 were considered for inclusion. |
T10 |
753-907 |
Sentence |
denotes |
Two independent researchers extracted data from eligible studies using a standardized data extraction sheet and then proceeded to cross check the results. |
T11 |
908-1049 |
Sentence |
denotes |
Data were pooled using a fixed- or random-effects model to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). |
T12 |
1050-1058 |
Sentence |
denotes |
Results: |
T13 |
1059-1184 |
Sentence |
denotes |
Three studies reported blood glucose and HbA1c according to the severity of COVID-19 and were included in this meta-analysis. |
T14 |
1185-1293 |
Sentence |
denotes |
The combined results showed that severe COVID-19 was associated with higher blood glucose (WMD 2.21, 95% CI: |
T15 |
1294-1316 |
Sentence |
denotes |
1.30-3.13, P < 0.001). |
T16 |
1317-1511 |
Sentence |
denotes |
In addition, HbA1c was slightly higher in patients with severe COVID-19 than those with mild COVID-19, yet this difference did not reach significance (WMD 0.29, 95% CI: -0.59 to 1.16, P = 0.52). |
T17 |
1512-1524 |
Sentence |
denotes |
Conclusions: |
T18 |
1525-1626 |
Sentence |
denotes |
This meta-analysis provides evidence that severe COVID-19 is associated with increased blood glucose. |
T19 |
1627-1745 |
Sentence |
denotes |
This highlights the need to effectively monitor blood glucose to improve prognosis in patients infected with COVID-19. |