LitCovid-sentences  

PubMed:33048372 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Hydroxychloroquine and Maintenance Immunosuppression Use in Kidney Transplant Recipients:
T2 90-113 Sentence denotes Analysis of Linked U.S.
T3 114-139 Sentence denotes Registry and Claims Data.
T4 140-284 Sentence denotes Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory effects used to treat systemic lupus erythematosus (SLE) and scleroderma.
T5 285-410 Sentence denotes The antiviral effects of HCQ have raised attention in the context of the COVID-19 pandemic, although safety is controversial.
T6 411-638 Sentence denotes We examined linkages of national transplant registry data with pharmaceutical claims and Medicare billing claims to study HCQ use among Medicare-insured kidney transplant recipients with SLE or scleroderma (2008-2017; N=1,820).
T7 639-726 Sentence denotes We compared three groups based on immunosuppression regimen 7-12 months posttransplant:
T8 727-884 Sentence denotes 1) tacrolimus (Tac)+mycophenolic acid (MPA)+prednisone (Pred) (referent group, 77.7%); 2) Tac+MPA+Pred+HCQ (16.5%); or 3) other immunosuppression+HCQ (5.7%).
T9 885-1188 Sentence denotes Compared to the referent group, recipients treated with other immunosuppression+HCQ had a 2-fold increased risk of abnormal ECG or QT prolongation (18.9% vs. 10.7%; aHR,1.12 1.963.42 , p=0.02) and ventricular arrhythmias (15.2% vs. 11.4%; aHR,1.00 1.813.29 , p=0.05) in the >1-to-3 years posttransplant.
T10 1189-1427 Sentence denotes Tac+MPA+Pred+HCQ was associated with increased risk of ventricular arrhythmias (13.5% vs. 11.4%; aHR,1.02 1.54 2.31 , p=0.04) and pancytopenia (35.9% vs. 31.4%; aHR,1.03 1.311.68 , p=0.03) compared to triple immunosuppression without HCQ.
T11 1428-1530 Sentence denotes However, HCQ-containing regimens were not associated with an increased risk of death or graft failure.
T12 1531-1694 Sentence denotes HCQ may be used safely in selected kidney transplant recipients in addition to their maintenance immunosuppression, although attention to arrhythmias is warranted.