| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-156 |
Sentence |
denotes |
A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections. |
| T2 |
157-372 |
Sentence |
denotes |
Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment. |
| T3 |
373-534 |
Sentence |
denotes |
Zinc is a vital microelement that actively supports respiratory epithelium barrier integrity, innate and adaptive immune functions, and inflammatory regulations. |
| T4 |
535-728 |
Sentence |
denotes |
Moreover, zinc may also prevent viral entry, suppress viral replication, and mitigate the damages due to oxidative stress and hyperinflammatory reaction in patients with respiratory infections. |
| T5 |
729-860 |
Sentence |
denotes |
Hinokitiol (β-thujaplicin) is a natural monoterpenoid and is considered as a safe zinc ionophore to help zinc transport into cells. |
| T6 |
861-1033 |
Sentence |
denotes |
It has been widely used in skin and oral care, and therapeutic products for its potent antiviral, antimicrobial, antifungal, anti-inflammatory, and anticancer applications. |
| T7 |
1034-1259 |
Sentence |
denotes |
The ongoing COVID-19 pandemic and the significant morbidity and mortality exist in the high-risk group of patients associated with other respiratory infections such as influenza, respiratory syncytial virus, and dengue fever. |
| T8 |
1260-1397 |
Sentence |
denotes |
There is an urgent need for the development of inexpensive, safe, and effective therapeutics to prevent and treat these viral infections. |
| T9 |
1398-1700 |
Sentence |
denotes |
Considering that hydroxychloroquine (HCQ), the most studied zinc ionophore drug for COVID-19, is linked to potentially serious side effects, we propose the implementation of hinokitiol as a zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and other viral infections. |
