LitCovid-sentences  

PubMed:33041111 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence.
T2 98-111 Sentence denotes INTRODUCTION:
T3 112-196 Sentence denotes There is a pressing need for COVID-19 transmission control and effective treatments.
T4 197-341 Sentence denotes We aim to evaluate the safety and effectiveness of SARS-CoV-2 pharmacologic therapies as of August 2, 2020 according to study level of evidence.
T5 342-350 Sentence denotes METHODS:
T6 351-428 Sentence denotes PubMed, ScienceDirect, Cochrane Library, JAMA Network and PNAS were searched.
T7 429-603 Sentence denotes The following keywords were used: ((COVID-19) OR (SARS-CoV-2)) AND ((((((therapeutics) OR (treatment)) OR (vaccine)) OR (hydroxychloroquine)) OR (antiviral)) OR (prognosis)).
T8 604-664 Sentence denotes Results included peer-reviewed studies published in English.
T9 665-673 Sentence denotes RESULTS:
T10 674-803 Sentence denotes 15 peer-reviewed articles met study inclusion criteria, of which 14 were RCTs and one was a systematic review with meta-analysis.
T11 804-975 Sentence denotes The following pharmacologic therapies were evaluated: chloroquine (CQ), hydroxychloroquine (HCQ), antivirals therapies, plasma therapy, anti-inflammatories, and a vaccine.
T12 976-987 Sentence denotes CONCLUSION:
T13 988-1262 Sentence denotes According to level 1 evidence reviewed here, the most effective SARS-Co-V-2 pharmacologic treatments include remdesivir for mild to severe disease, and a triple regimen therapy consisting of lopinavir-ritonavir, ribavirin and interferon beta-1b for mild to moderate disease.
T14 1263-1354 Sentence denotes Also, dexamethasone significantly reduced mortality in those requiring respiratory support.
T15 1355-1449 Sentence denotes However, there is still a great need for detailed level 1 evidence on pharmacologic therapies.