LitCovid-sentences  

PubMed:33035581 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Can endolysosomal deacidification and inhibition of autophagy prevent severe COVID-19?
T2 87-383 Sentence denotes The possibility is examined that immunomodulatory pharmacotherapy may be clinically useful in managing the pandemic coronavirus disease 2019 (COVID-19), known to result from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense single-stranded RNA virus.
T3 384-652 Sentence denotes The dominant route of cell entry of the coronavirus is via phagocytosis, with ensconcement in endosomes thereafter proceeding via the endosomal pathway, involving transfer from early (EEs) to late endosomes (LEs) and ultimately into lysosomes via endolysosomal fusion.
T4 653-719 Sentence denotes EE to LE transportation is a rate-limiting step for coronaviruses.
T5 720-828 Sentence denotes Hence inhibition or dysregulation of endosomal trafficking could potentially inhibit SARS-CoV-2 replication.
T6 829-965 Sentence denotes Furthermore, the acidic luminal pH of the endolysosomal system is critical for the activity of numerous pH-sensitive hydrolytic enzymes.
T7 966-1096 Sentence denotes Golgi sub-compartments and Golgi-derived secretory vesicles also depend on being mildly acidic for optimal function and structure.
T8 1097-1306 Sentence denotes Activation of endosomal toll-like receptors by viral RNA can upregulate inflammatory mediators and contribute to a systemic inflammatory cytokine storm, associated with a worsened clinical outcome in COVID-19.
T9 1307-1727 Sentence denotes Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production.
T10 1728-1827 Sentence denotes It is also noteworthy that SARS-CoV-2 inhibits autophagy, predisposing infected cells to apoptosis.
T11 1828-1981 Sentence denotes It is therefore also suggested that further pharmacological inhibition of autophagy might encourage the apoptotic clearance of SARS-CoV-2-infected cells.