Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-60 |
Sentence |
denotes |
Analysis of cardiopulmonary findings in COVID-19 fatalities: |
T2 |
61-143 |
Sentence |
denotes |
High incidence of pulmonary artery thrombi and acute suppurative bronchopneumonia. |
T3 |
144-346 |
Sentence |
denotes |
Since its recognition in December 2019, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread globally causing a pandemic that represents the greatest medical challenge in decades. |
T4 |
347-515 |
Sentence |
denotes |
The aim of the study was to evaluate the spectrum of cardiopulmonary pathology of COVID-19 based on (non-minimal invasive) autopsies performed on 14 COVID-19 decedents. |
T5 |
516-582 |
Sentence |
denotes |
Bilateral diffuse alveolar damage (DAD) was found in all patients. |
T6 |
583-718 |
Sentence |
denotes |
Superimposed acute bronchopneumonia was present in 11 of 14 (78.6%) patients and was considered the major cause of death in 2 patients. |
T7 |
719-799 |
Sentence |
denotes |
A key finding was the presence of thrombotic/thromboembolic vascular occlusions. |
T8 |
800-843 |
Sentence |
denotes |
We classified 5 types of pulmonary thrombi: |
T9 |
844-1238 |
Sentence |
denotes |
1. capillary microthrombi (11/14, 78.6%); 2. partially organized thrombi in mid-sized pulmonary arteries with complete vessel occlusion; 3. non-organized thrombi in mid-sized pulmonary arteries that did not completely fill out the vessel lumen and probably represented thromboemboli rather than thrombosis; 4. bone marrow emboli (1/14, 7.1%); and 5. septic pulmonary thromboemboli (1/14, 7.1%). |
T10 |
1239-1376 |
Sentence |
denotes |
Pulmonary thrombi in mid-sized arteries were noted in 5 of 14 (35.7%) patients, causing pulmonary infarction and/or pulmonary hemorrhage. |
T11 |
1377-1585 |
Sentence |
denotes |
All patients had evidence of chronic cardiac disease, including myocardial hypertrophy (13/14, 92.9%), mild to marked coronary artery atherosclerosis (14/14, 100%) and focal myocardial fibrosis (3/14, 21.4%). |
T12 |
1586-1804 |
Sentence |
denotes |
Acute myocardial infarction was found as concurrent cause of death in 3 (21.4%) patients, and significant cardiac hypertrophy (heart weight 750 g) was present in 1 (7.1%) patient with ATTR-positive cardiac amyloidosis. |
T13 |
1805-2041 |
Sentence |
denotes |
The autopsy findings confirm that COVID-19 is a systemic disease, with major involvement of the lungs, that increases the risk of cardiac and vascular complications including acute myocardial injury and thrombotic/thromboembolic events. |
T14 |
2042-2162 |
Sentence |
denotes |
Secondary acute bronchopneumonia is a common complication in patients with COVID-19 and may be the major cause of death. |