| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-135 |
Sentence |
denotes |
Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection. |
| T2 |
136-149 |
Sentence |
denotes |
INTRODUCTION: |
| T3 |
150-314 |
Sentence |
denotes |
Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc). |
| T4 |
315-325 |
Sentence |
denotes |
OBJECTIVE: |
| T5 |
326-471 |
Sentence |
denotes |
To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals. |
| T6 |
472-480 |
Sentence |
denotes |
METHODS: |
| T7 |
481-688 |
Sentence |
denotes |
At the beginning of COVID-19 pandemic patients admitted to our hospital were treated with the empiric association of HY/RD; one week later the therapeutic protocol was modified with the combination of HY/AZ. |
| T8 |
689-769 |
Sentence |
denotes |
Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy. |
| T9 |
770-855 |
Sentence |
denotes |
We prospectively enrolled 113 patients (61 in the HY/RD group-52 in the HY/AZ group). |
| T10 |
856-864 |
Sentence |
denotes |
RESULTS: |
| T11 |
865-1055 |
Sentence |
denotes |
A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both). |
| T12 |
1056-1105 |
Sentence |
denotes |
23 patients (21.2%) had a QTc > 500 ms at 7 days. |
| T13 |
1106-1424 |
Sentence |
denotes |
The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (≥ 440 ms for female and ≥ 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001). |
| T14 |
1425-1491 |
Sentence |
denotes |
One patient per group suffered a malignant ventricular arrhythmia. |
| T15 |
1492-1503 |
Sentence |
denotes |
CONCLUSION: |
| T16 |
1504-1628 |
Sentence |
denotes |
Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days. |
| T17 |
1629-1762 |
Sentence |
denotes |
The risk of developing malignant arrhythmias remained relatively low when these drugs were administered for a limited period of time. |
