LitCovid-sentences  

PubMed:32633815 JSONTXT 15 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-38 Sentence denotes An update on the origin of SARS-CoV-2:
T2 39-178 Sentence denotes Despite closest identity, bat (RaTG13) and pangolin derived coronaviruses varied in the critical binding site and O-linked glycan residues.
T3 179-427 Sentence denotes The initial cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) occurred in Wuhan, China, in December 2019 and swept the world by 23 June 2020 with 8 993 659 active cases, 469 587 deaths across 216 countries, areas or territories.
T4 428-508 Sentence denotes This strongly implies global transmission occurred before the lockdown of China.
T5 509-606 Sentence denotes However, the initial source's transmission routes of SARS-CoV-2 remain obscure and controversial.
T6 607-706 Sentence denotes Research data suggest bat (RaTG13) and pangolin carried CoV were the proximal source of SARS-CoV-2.
T7 707-860 Sentence denotes In this study, we used systematic phylogenetic analysis of Coronavirinae subfamily along with wild type human SARS-CoV, MERS-CoV, and SARS-CoV-2 strains.
T8 861-949 Sentence denotes The key residues of the receptor-binding domain (RBD) and O-linked glycan were compared.
T9 950-1125 Sentence denotes SARS-CoV-2 strains were clustered with RaTG13 (97.41% identity), Pangolin-CoV (92.22% identity) and Bat-SL-CoV (80.36% identity), forms a new clade-2 in lineage B of beta-CoV.
T10 1126-1183 Sentence denotes The alignments of RBD contact residues to ACE2 justified?
T11 1184-1302 Sentence denotes Those SARS-CoV-2 strains sequences were 100% identical by each other, significantly varied in RaTG13 and pangolin-CoV.
T12 1303-1422 Sentence denotes SARS-CoV-2 has a polybasic cleavage site with an inserted sequence of PRRA compared to RaTG13 and only PRR to pangolin.
T13 1423-1644 Sentence denotes Only serine (Ser) in pangolin and both threonine (Thr) and serine (Ser) O-linked glycans were seen in RaTG13, suggesting that a detailed study needed in pangolin (Manis javanica) and bat (Rhinolophus affinis) related CoV.