LitCovid-sentences  

PubMed:32442082 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
T2 85-87 Sentence denotes 1.
T3 88-282 Sentence denotes Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019.
T4 283-472 Sentence denotes Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing.
T5 473-599 Sentence denotes Recently, Mao et al. [1] investigated the penetration potential of SARS-CoV-2 into the central nervous system in 214 patients.
T6 600-838 Sentence denotes They reported that 36.4% of the patients had some neurologic findings which are ranged from nonspecific manifestations, e.g., dizziness, headache, and seizure, to specific manifestations, e.g., loss of sense of smell or taste, and stroke.
T7 839-936 Sentence denotes Whether these common symptoms in their patients are related to SARS-CoV-2 infection is not known.
T8 937-1205 Sentence denotes However, it is important to mention here that dramatic neurologic symptoms, i.e., depressed level of consciousness, seizure, and stroke, are common in the patients at the late stage of the disease, accounting for increased mortality rate in severely affected patients.
T9 1206-1376 Sentence denotes Nevertheless, to objectively delve into the direct relation between the neurologic symptoms and COVID-19, medical comorbidities of patients should also be considered [2].
T10 1377-1556 Sentence denotes Further studies are needed because we are in the midst of an ongoing pandemic of COVID-19, and neurologists may be confronted with new-onset neurologic symptoms owing to COVID-19.
T11 1557-1725 Sentence denotes SARS-CoV-2 penetrates via human angiotensin-converting enzyme-2 receptor (ACE-2) that was also utilized by severe acute respiratory syndrome coronavirus (SARS CoV) [3].
T12 1726-1844 Sentence denotes Glial cells and neurons have been reported to express ACE-2 receptors, which make them a potential target of COVID-19.
T13 1845-1949 Sentence denotes It was indicated that SARS CoV causes neuronal death by invading the brain via olfactory epithelium [4].
T14 1950-2142 Sentence denotes The electron microscopy, immunohistochemistry, and real-time reverse transcription- PCR findings have corroborated the presence of SARS-CoV in the brain tissue [4] and cerebrospinal fluid [5].
T15 2143-2359 Sentence denotes Together, it can be speculated that SARS-CoV-2 can affect the brain by penetrating the brain via the cribriform plate, which can account for the early findings of the COVID-19 like altered sense of smell or hyposmia.
T16 2360-2526 Sentence denotes Because SARS-CoV-2 causes severe respiratory symptoms in people aged 60 years and older, it has important implications for patients with Alzheimer's disease (AD) [6].
T17 2527-2655 Sentence denotes Therefore, in the countries that have taken action to the virus, clinic studies of AD have been stopped to protect the patients.
T18 2656-2780 Sentence denotes However, rigorous quarantine of elders has aborted clinic trials and experimental studies conducted with transgenic animals.
T19 2781-2870 Sentence denotes Transgenic models are quite expensive; the loss of these animals has costly consequences.
T20 2871-2991 Sentence denotes There is no doubt that this storm will stop, but its catastrophic effects on dementia research will continue for a time.
T21 2992-3125 Sentence denotes Thus, dementia researchers and pharmaceutical companies should determine an emergency action plan to exit the chaos of this pandemic.
T22 3126-3235 Sentence denotes Here, we listed some challenges in dementia research during the COVID-19 outbreak and table some suggestions.
T23 3236-3297 Sentence denotes All countries try to control SARS-CoV-2 by social distancing.
T24 3298-3400 Sentence denotes Therefore, neurology clinics were closed, and routine examination of Alzheimer's patients was stopped.
T25 3401-3522 Sentence denotes However, the lockdown of patients with AD caused clinical studies to stop. which has severely affected dementia research.
T26 3523-3672 Sentence denotes Additionally, the arrest of experimental studies due to the closing of universities in two hundred countries also deprives experimental achievements.
T27 3673-3885 Sentence denotes The closing of universities may lead to data loss, death of expensive transgenic animals, international researchers to be faced with visa problems, and be lost the laboratory staff whose contract has expired [7].
T28 3886-4079 Sentence denotes It is impossible that forecasting when this COVID-19 pandemic will end is impossible and thus, it is essential that a solution be developed to continue dementia studies on Alzheimer's patients.
T29 4080-4178 Sentence denotes Remote monitoring of the patients with the use of technology is in the lead of possible solutions.
T30 4179-4346 Sentence denotes Clinicians can continue to follow their patients by telemedicine [8], but extended lockdown of patients may cause depression in both patients and their caregivers [9].
T31 4347-4419 Sentence denotes It is also known that movement restriction exacerbates AD symptoms [10].
T32 4420-4523 Sentence denotes The monitorization of the patient in this condition with telemedicine would not provide objective data.
T33 4524-4664 Sentence denotes In addition, when patients living in rural areas are considered, it will not be a surprise that reaching equally all patients is impossible.
T34 4665-4861 Sentence denotes Therefore, a collective action plan protecting dementia research during the COVID-19 outbreak should be prepared by a consortium of pharmaceutical companies, researchers, clinicians, and patients.
T35 4862-4937 Sentence denotes Data loss is in the lead of expected problems during the COVID-19 outbreak.
T36 4938-5061 Sentence denotes For example, the planned ending dates of phase 2/3 trials of gantenerumab (Roche) and solanezumab (Lilly) were missed [11].
T37 5062-5163 Sentence denotes It is highly essential that patients be monitored from their homes with telemedicine to protect them.
T38 5164-5263 Sentence denotes Nonetheless, it is not sufficient for the continuation of clinical trials and experimental studies.
T39 5264-5387 Sentence denotes We suggest that patients of phase trails should be isolated in fully-equipped nursing homes managed by qualified personnel.
T40 5388-5587 Sentence denotes In this way, the patients can be more effectively protected from SARS-CoV-2 and the depression caused by the lockdown.Young family members going out for basic needs could infect older family members.
T41 5588-5695 Sentence denotes Also, patients with AD pay less attention to hand hygiene, which makes them more susceptible to SARS-CoV-2.
T42 5696-5770 Sentence denotes Moreover, cats have recently been shown to be infected by SARS-CoV-2 [12].
T43 5771-5937 Sentence denotes Patients with AD may not follow directions of neurologists on telemedicine and thus, the interaction of Alzheimer's patients with pets can cause a dangerous scenario.
T44 5938-6084 Sentence denotes Consequently, the lockdown of patients with dementia in their homes might not be an appropriate exit strategy for the future of dementia research.
T45 6085-6276 Sentence denotes On the other hand, it is important to mention here that the nursing home capacity of the United States may not be sufficient for 5,8 million Alzheimer's patients aged 65 years and older [13].
T46 6277-6389 Sentence denotes Thus, we highlight that only the patients involved in the clinic trails should be followed in the nursing homes.
T47 6390-6461 Sentence denotes The other patients can be monitored with telemedicine from their homes.
T48 6462-6529 Sentence denotes The data will hardly be lost in patients isolated in nursing homes.
T49 6530-6632 Sentence denotes In this strategy, secondary risk factors affecting the clinic trails like depression are also removed.
T50 6633-6758 Sentence denotes The motivations of clinicians and researchers is as important as the patients in the catastrophic atmosphere of the outbreak.
T51 6759-6849 Sentence denotes Governments, media, and funders can support the motivations of clinicians and researchers.
T52 6850-7032 Sentence denotes For example, research funders and pharmaceutical companies can extend project deadlines and provide an additional promotion to the researchers who have completed their clinic trails.
T53 7033-7140 Sentence denotes Consequently, a global action plan should be prepared to block SARS-CoV-2 penetration to dementia research.
T54 7141-7331 Sentence denotes At first glance, it may be thought that the most appropriate strategy for patients with dementia is social isolation in their homes during the outbreak as in healthy young people and elders.
T55 7332-7515 Sentence denotes However, we suggest that isolating patients with dementia in fully-equipped nursing homes can be a more appropriate exit strategy for the protection of dementia patients and research.