LitCovid-sentences  

PMC:7799378 / 889-3529 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T14 0-12 Sentence denotes Introduction
T15 13-101 Sentence denotes SARS-CoV-2, the pathogenic agent of COVID-19, has become the center of global attention.
T16 102-223 Sentence denotes As of November, 2020, COVID-19 has affected more than 45 million people and caused over one million deaths worldwide [1].
T17 224-318 Sentence denotes The RNA virus SARS-CoV-2 is a member of the genus Betacoronavirus in the family Coronaviridae.
T18 319-402 Sentence denotes A majority of individuals (80%) recover from the infection without hospitalisation.
T19 403-516 Sentence denotes About 20% of patients develop serious symptoms and need oxygen therapy, while 5% of those require intensive care.
T20 517-676 Sentence denotes The clinical manifestations of COVID-19 include fever, pneumonia, serum SARS-CoV-2 nucleic acid in the blood (RNAemia), and ground-glass opacities in the lung.
T21 677-782 Sentence denotes Individuals with COVID-19 can exhibit cold-like symptoms; however, 15% of them have severe complications.
T22 783-961 Sentence denotes These complications, which result in death, include sepsis, thromboembolism as well as multiple organ failure including injury of the lung, heart, liver, brain, and kidney [2–4].
T23 962-1123 Sentence denotes Respiratory distress accompanied by a systemic inflammatory response, such as increased cytokine secretions, is common in individuals with severe COVID-19 [5–7].
T24 1124-1278 Sentence denotes In response to viral infection, dysregulated hyperinflammation leads to acute lung injury (ALI) manifest as an acute respiratory distress syndrome (ARDS).
T25 1279-1387 Sentence denotes These pathological networks are closely associated with oxidative stress and an imbalanced redox status [8].
T26 1388-1556 Sentence denotes However, how glucose-6-phosphate dehydrogenase (G6PD), a well-known antioxidant enzyme as well as a pro-oxidant enzyme affects COVID-19 has not been carefully examined.
T27 1557-1653 Sentence denotes G6PD deficiency is a common and X-linked enzymopathy affecting approximately 400 million people.
T28 1654-1750 Sentence denotes G6PD mutations are carried by females, with 90% of males with the genetic defect being affected.
T29 1751-1885 Sentence denotes These affected individuals suffer from a hemolytic crisis after being exposed to oxidants or microbes, including coronaviruses [9–11].
T30 1886-2022 Sentence denotes Geographically, G6PD deficiency affects individuals in African, Mediterranean, Southeast, and South Asian, and Latin American countries.
T31 2023-2276 Sentence denotes The fact that G6PD deficiency is more common in some European countries, like Italy and Spain along with the fact that these Mediterranean countries are severely affected by COVID-19 pandemic and have high fatality rates may not be coincidental [12,13].
T32 2277-2394 Sentence denotes This raises the spectre that “G6PD deficiency” can be a predisposing factor that causes severe COVID-19 illness [14].
T33 2395-2536 Sentence denotes This review aims to discuss the potential link between G6PD and viral infections including COVID-19 from the standpoint of redox homeostasis.
T34 2537-2640 Sentence denotes The alternative therapies for COVID-19, including antioxidants and anti-aging drugs are also discussed.