| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T75 |
0-107 |
Sentence |
denotes |
Redox homeostasis mediated by G6PD is implicated in the modulation of the immune response and inflammation. |
| T76 |
108-188 |
Sentence |
denotes |
G6PD deficiency is correlated with an increased risk of neonatal sepsis [32–34]. |
| T77 |
189-280 |
Sentence |
denotes |
Infants and trauma patients with G6PD deficiency display altered cytokine profiles [35–37]. |
| T78 |
281-563 |
Sentence |
denotes |
Glucose overload-induced vascular inflammation in human aortic smooth muscle cells reveals that IL-1β enhances glucose transport and metabolism through the PPP, resulting in an increased pro-inflammatory response, including NF-κB and NOX activation and iNOS protein expression [38]. |
| T79 |
564-705 |
Sentence |
denotes |
Blockade of G6PD with either the chemical inhibitor 6-aminonicotinamide, 6-AN, or siRNA against G6PD abolishes the pro-inflammatory response. |
| T80 |
706-809 |
Sentence |
denotes |
G6PD deficiency can elevate inflammation through NF-κB-mediated pro-inflammatory cytokine upregulation. |
| T81 |
810-985 |
Sentence |
denotes |
An in vitro HepG2 cell model of lipid-induced chronic hepatic inflammation indicates that G6PD knockdown enhances a pro-inflammatory cytokine response and ROS production [39]. |
| T82 |
986-1181 |
Sentence |
denotes |
Treatment with the anti-oxidative enzyme glutathione peroxidase or the anti-inflammatory agent curcumin in HepG2 cells inhibits the secretion and expression of the pro-inflammatory cytokine IL-8. |
| T83 |
1182-1295 |
Sentence |
denotes |
These findings suggest that G6PD modulates the pro-inflammatory response in an induced and cell-dependent manner. |
