LitCovid-sentences  

PMC:7799378 / 16939-21781 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T141 0-113 Sentence denotes Impaired NET formation and inflammasome activation in G6PD-deficiency and its possible effect on viral infections
T142 114-173 Sentence denotes Neutrophils are among the key players in the immune system.
T143 174-323 Sentence denotes The role of neutrophils in bacterial or fungal infection is well known, yet their influence on the anti-viral response has not been established [87].
T144 324-440 Sentence denotes In response to infection, stimulated neutrophils release chromosomal DNA for trapping and killing invading microbes.
T145 441-512 Sentence denotes The chromatin trap is known as the neutrophil extracellular trap (NET).
T146 513-780 Sentence denotes It mediates the control of viruses, such as seen with human HIV and chikungunya viral infections [88, 89], whereas it can contribute to other viral infections, including in non-human primates with SIV and Hep-2 cells infected with respiratory syncytial virus [90,91].
T147 781-963 Sentence denotes The cytotoxic effect on lung epithelium and endothelium has linked NETs to several pulmonary diseases, including acute lung injury, asthma, COPD, cystic fibrosis, and pneumonia [92].
T148 964-1066 Sentence denotes NET formation can be inhibited by NAC and DPI, indicating the involvement of oxidative stress and NOX.
T149 1067-1175 Sentence denotes A metabolic shift towards the PPP is required for the NET formation induced by amyloid fibrils and PMA [93].
T150 1176-1290 Sentence denotes G6PD-derived NADPH can serve as a substrate for NOX, which generates superoxide and stimulates NET formation [17].
T151 1291-1428 Sentence denotes Neutrophils from individuals with the G6PD Taiwan-Hakka variant are equally effective as normal individuals regarding NET formation [94].
T152 1429-1555 Sentence denotes However, defective NET formation and NOX activity are observed in neutrophils of individuals with severe G6PD deficiency [95].
T153 1556-1664 Sentence denotes The absence of NET formation is found in NOX deficiency associated with chronic granulomatous disease (CGD).
T154 1665-1743 Sentence denotes Severe G6PD deficiency may mimic impaired NOX resulting in dysfunctional NETs.
T155 1744-1800 Sentence denotes Elevated NET levels are found in COVID-19 patients [96].
T156 1801-1997 Sentence denotes NET formation is considered as a driver of COVID-19, since NET formation may contribute to tissue damage, organ injury, and mortality as indicated by autopsy specimens from COVID-19 patients [97].
T157 1998-2179 Sentence denotes The by-product of NETs, such as elastase, is involved in the pathogenesis of COVID-19 by facilitating SARS-CoV-2 entry and causing hypertension, thrombosis, and vasculitis [98–100].
T158 2180-2328 Sentence denotes The tissue damage leading to excessive oxidative stress creates a vicious cycle by increasing NET formation and distressing adaptive immunity [101].
T159 2329-2475 Sentence denotes Increased NETs are associated with hyperinflammation and in COVID-19 patients they amplify the severity and mortality associated with the disease.
T160 2476-2667 Sentence denotes Targeting NETs and its feedback loop, with elastase, DNase-1, or inhibitory peptides as well as IL-1β, are potential therapeutic interventions for reducing the severity of COVID-19 [102,103].
T161 2668-2781 Sentence denotes The inflammasome is part of the innate immune system that regulates effector cells during inflammation [104–107].
T162 2782-3057 Sentence denotes Inflammasomes are cytosolic protein complexes consisting of multiple oligomeric molecules that detect cell-damaging agents and pathogenic factors by recognizing danger-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMP), respectively [104].
T163 3058-3169 Sentence denotes Through cleavage of pro-IL-1β and pro-IL-18, they promote the secretion of the active forms of IL-1β and IL-18.
T164 3170-3276 Sentence denotes Long-term exposure of the host to viruses causes dysregulated inflammation and autoinflammatory disorders.
T165 3277-3433 Sentence denotes Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is triggered by viral replication and leads to the destruction of viruses [105].
T166 3434-3630 Sentence denotes The murine coronavirus mouse hepatitis virus (MHV) activates NLRP3 inflammasomes and induces proinflammatory programmed cell death by panoptosis (pyroptosis, apoptosis, and necroptosis) [106,107].
T167 3631-3806 Sentence denotes The deleterious effects on the host due to inflammasome impairment indicate that balanced regulation of inflammasomes is crucial for the immune response and antiviral defense.
T168 3807-3896 Sentence denotes Inflammasome activation causes a cytokine storm in both SARS and COVID-19 patients [108].
T169 3897-4048 Sentence denotes It is proposed that the heterogeneous response in COVID-19 patients due to the lack of immune fitness fails to properly reduce inflammasome activation.
T170 4049-4169 Sentence denotes This leads to enhanced severity of COVID-19, that is associated with a cytokine storm and extensive tissue damage [109].
T171 4170-4387 Sentence denotes G6PD deficiency downregulates IL-1β expression and impairs inflammasome activation upon LPS and ATP/nigericin stimulation in PBMCs (peripheral blood mononuclear cells) and THP-1 cells (human monocyte cell line) [110].
T172 4388-4550 Sentence denotes The impaired inflammasome activation is attributed to reduced ROS production via NOX, while H2O2 stimulates inflammasome activation in G6PD-knockdown THP-1 cells.
T173 4551-4842 Sentence denotes This results in weaken bactericidal activity against Staphylococcus aureus and Escherichia coli in G6PD-knockdown THP-1 cells, indicating that G6PD is required for the maintenance of the innate immune response, inflammasome activation, and pathogen clearance through redox homeostasis [110].