PMC:7799377 / 17579-20962 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T119 0-8 Sentence denotes COVID-19
T120 9-127 Sentence denotes Neurological symptoms have been sporadically reported in COVID-19 patients but have not yet been well studied [48,49].
T121 128-252 Sentence denotes The current body of evidence suggests that the SARS-CoV-2 can affect the nervous system in previously unsuspected ways [50].
T122 253-346 Sentence denotes The neuroinvasive capabilities of the SARS-CoV-2 doubtless exist but remain to be elucidated.
T123 347-474 Sentence denotes Observed neurological symptoms of COVID-19 include febrile seizures, convulsions, mental status changes, and encephalitis [51].
T124 475-632 Sentence denotes Among the most commonly reported possibly neurological symptoms of COVID-19 are nonspecific symptoms, such as headache, myalgia, dizziness, and fatigue [21].
T125 633-786 Sentence denotes In a study at a single center in China (n = 214), 36.4% (n = 78) of hospitalized COVID-19 patients had what were identified as neurological symptoms[52].
T126 787-961 Sentence denotes In a multicenter retrospective study from Europe of 417 patients who recovered from mild to moderate COVID-19, 86% reported olfactory dysfunction and 88% problems with taste.
T127 962-1061 Sentence denotes In fact, in 12% of patients, the loss of the sense of smell was the first symptom of COVID-19 [53].
T128 1062-1354 Sentence denotes The loss of smell has emerged as being more prevalent among patients infected with COVID-19 than patients infected with other viruses or with other types of respiratory conditions [54] and has been recommended as a symptom that may help guide earlier diagnosis and treatment of COVID-19 [55].
T129 1355-1483 Sentence denotes In a meta-analysis (n = 1,627 patients, 10 studies), a loss of the sense of smell was reported in 53% of COVID-19 patients [55].
T130 1484-1584 Sentence denotes It appears that the frequency of neurological symptoms is associated with COVID-19 disease severity.
T131 1585-1843 Sentence denotes In the aforementioned study of 214 hospitalized patients with COVID-19 infection (41% severe and 59% non-severe disease), severe patients were more likely than non-severe patients to have neurologically related manifestations (45.5% vs. 30.2%, respectively).
T132 1844-2107 Sentence denotes In this study, the most frequently reported neurological manifestations for severe and non-severe patients, respectively, were acute cerebrovascular disease (5.7% vs. 0.8%), impaired consciousness (14.8% vs. 2.4%) and skeletal muscle injury (19.3% vs. 4.8%) [52].
T133 2108-2230 Sentence denotes This does not take into account more diffuse symptoms, such as confusion or headache, which may also be neurological [51].
T134 2231-2319 Sentence denotes Most COVID-19 patients seem to exhibit pulmonary symptoms before neurological ones [49].
T135 2320-2546 Sentence denotes About a third of diagnosed COVID-19 patients have some form of symptomology of suspected neurological origin, which might include headache, dizziness, impaired consciousness, ataxia, epilepsy, and cerebrovascular disease [49].
T136 2547-2690 Sentence denotes Besides an impaired or absent sense of smell or taste, vision disturbances, neuralgia, and skeletal muscle damage have also been reported [49].
T137 2691-2894 Sentence denotes Nucleic acid from the SARS-CoV-2 virus has been detected in the cerebrospinal fluid of patients, and the virus itself has been identified in brain tissue on autopsy of patients who died of COVID-19 [49].
T138 2895-2974 Sentence denotes Such findings are rare but confirm that the SARS-CoV-2 virus can enter the CNS.
T139 2975-3204 Sentence denotes A 24-year-old Japanese man with COVID-19 presented with generalized epileptic seizures and decreased consciousness; RNA from the SARS-CoV-2 was not detectable in his nasopharynx but was identified in the cerebrospinal fluid [56].
T140 3205-3383 Sentence denotes Using a polymerase chain reaction (PCR) assay, the SARS-CoV-2 was likewise detected in the cerebrospinal fluid of an obese 40-year-old female COVID-19 patient with diabetes [57].