Id |
Subject |
Object |
Predicate |
Lexical cue |
T119 |
0-8 |
Sentence |
denotes |
COVID-19 |
T120 |
9-127 |
Sentence |
denotes |
Neurological symptoms have been sporadically reported in COVID-19 patients but have not yet been well studied [48,49]. |
T121 |
128-252 |
Sentence |
denotes |
The current body of evidence suggests that the SARS-CoV-2 can affect the nervous system in previously unsuspected ways [50]. |
T122 |
253-346 |
Sentence |
denotes |
The neuroinvasive capabilities of the SARS-CoV-2 doubtless exist but remain to be elucidated. |
T123 |
347-474 |
Sentence |
denotes |
Observed neurological symptoms of COVID-19 include febrile seizures, convulsions, mental status changes, and encephalitis [51]. |
T124 |
475-632 |
Sentence |
denotes |
Among the most commonly reported possibly neurological symptoms of COVID-19 are nonspecific symptoms, such as headache, myalgia, dizziness, and fatigue [21]. |
T125 |
633-786 |
Sentence |
denotes |
In a study at a single center in China (n = 214), 36.4% (n = 78) of hospitalized COVID-19 patients had what were identified as neurological symptoms[52]. |
T126 |
787-961 |
Sentence |
denotes |
In a multicenter retrospective study from Europe of 417 patients who recovered from mild to moderate COVID-19, 86% reported olfactory dysfunction and 88% problems with taste. |
T127 |
962-1061 |
Sentence |
denotes |
In fact, in 12% of patients, the loss of the sense of smell was the first symptom of COVID-19 [53]. |
T128 |
1062-1354 |
Sentence |
denotes |
The loss of smell has emerged as being more prevalent among patients infected with COVID-19 than patients infected with other viruses or with other types of respiratory conditions [54] and has been recommended as a symptom that may help guide earlier diagnosis and treatment of COVID-19 [55]. |
T129 |
1355-1483 |
Sentence |
denotes |
In a meta-analysis (n = 1,627 patients, 10 studies), a loss of the sense of smell was reported in 53% of COVID-19 patients [55]. |
T130 |
1484-1584 |
Sentence |
denotes |
It appears that the frequency of neurological symptoms is associated with COVID-19 disease severity. |
T131 |
1585-1843 |
Sentence |
denotes |
In the aforementioned study of 214 hospitalized patients with COVID-19 infection (41% severe and 59% non-severe disease), severe patients were more likely than non-severe patients to have neurologically related manifestations (45.5% vs. 30.2%, respectively). |
T132 |
1844-2107 |
Sentence |
denotes |
In this study, the most frequently reported neurological manifestations for severe and non-severe patients, respectively, were acute cerebrovascular disease (5.7% vs. 0.8%), impaired consciousness (14.8% vs. 2.4%) and skeletal muscle injury (19.3% vs. 4.8%) [52]. |
T133 |
2108-2230 |
Sentence |
denotes |
This does not take into account more diffuse symptoms, such as confusion or headache, which may also be neurological [51]. |
T134 |
2231-2319 |
Sentence |
denotes |
Most COVID-19 patients seem to exhibit pulmonary symptoms before neurological ones [49]. |
T135 |
2320-2546 |
Sentence |
denotes |
About a third of diagnosed COVID-19 patients have some form of symptomology of suspected neurological origin, which might include headache, dizziness, impaired consciousness, ataxia, epilepsy, and cerebrovascular disease [49]. |
T136 |
2547-2690 |
Sentence |
denotes |
Besides an impaired or absent sense of smell or taste, vision disturbances, neuralgia, and skeletal muscle damage have also been reported [49]. |
T137 |
2691-2894 |
Sentence |
denotes |
Nucleic acid from the SARS-CoV-2 virus has been detected in the cerebrospinal fluid of patients, and the virus itself has been identified in brain tissue on autopsy of patients who died of COVID-19 [49]. |
T138 |
2895-2974 |
Sentence |
denotes |
Such findings are rare but confirm that the SARS-CoV-2 virus can enter the CNS. |
T139 |
2975-3204 |
Sentence |
denotes |
A 24-year-old Japanese man with COVID-19 presented with generalized epileptic seizures and decreased consciousness; RNA from the SARS-CoV-2 was not detectable in his nasopharynx but was identified in the cerebrospinal fluid [56]. |
T140 |
3205-3383 |
Sentence |
denotes |
Using a polymerase chain reaction (PCR) assay, the SARS-CoV-2 was likewise detected in the cerebrospinal fluid of an obese 40-year-old female COVID-19 patient with diabetes [57]. |