LitCovid-sentences  

PMC:7799377 / 1693-5629 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T18 0-12 Sentence denotes Introduction
T19 13-263 Sentence denotes The neuroinvasive potential of the Severe Acute Respiratory Syndrome novel coronavirus, SARS-CoV-2, is being recognized, with enhanced awareness that the associated infection, Coronavirus Diseases 2019 (COVID-19), might result in neurological injury.
T20 264-419 Sentence denotes Indeed, there is a growing body of evidence to suggest that a subset of COVID-19 patients will experience neurological manifestations of the infection [1].
T21 420-864 Sentence denotes Since genomic studies show that the SARS-CoV-2 virus has similar homological sequences with two of its beta-coronavirus predecessors, the SARS-CoV associated with Severe Acute Respiratory Syndrome (SARS) [2] and the virus associated with Middle Eastern Respiratory Syndrome (MERS) [3], it is helpful to review the neurological symptoms of these two earlier diseases as the plausible link between COVID-19 and neurological symptoms are explored.
T22 865-1001 Sentence denotes Furthermore, the pathophysiological pathways of these three conditions (COVID-19, SARS, and MERS) might be expected to be similar [4–6].
T23 1002-1158 Sentence denotes Neurotropism has been observed in both MERS and SARS [7–9], and there are early findings of certain neurological manifestations in COVID-19 patients [4,10].
T24 1159-1301 Sentence denotes The RNA of the SARS-CoV-2 virus has been identified in the cerebrospinal fluid of a COVID-19 patient, demonstrating its neurotropic potential.
T25 1302-1527 Sentence denotes It is clinically relevant to determine how the SARS-CoV-2 virus can access the central nervous system (CNS) and whether the neuronal injury caused by the virus might be connected to the injury of the autonomic nervous system.
T26 1528-1656 Sentence denotes The transmission of a novel infectious pathogen among humans such as the SARS-CoV-2 may be complicated, but it is far from rare.
T27 1657-1749 Sentence denotes As many as 75% of emerging human infections have some connection to a zoonotic disease [11].
T28 1750-2108 Sentence denotes Typically, viral, bacterial, fungal, or parasitical pathogens may emerge due to one or a combination of factors: human and animal interaction, changes in human or animal behavior, consumption of exotic animal foods, globalization, world travel, or things that disrupt human and animal interactions, such as wars, natural disasters, and environmental changes.
T29 2109-2294 Sentence denotes The pathogen itself may play a role in its pattern of emergence by mutation; in some instances, humans may facilitate the rapid progress of these mutations by the use of antimicrobials.
T30 2295-2412 Sentence denotes Thus, while often multifactorial and complex, the sudden emergence of a novel infectious agent is not a novelty [12].
T31 2413-2559 Sentence denotes The novel SARS-CoV-2 virus, which first appeared in 2019, is just one of several coronaviruses that have caused epidemics in the past two decades.
T32 2560-2754 Sentence denotes These pathogens are sometimes able to adapt to new hosts, as occurred with the zoonotic SARS-CoV-2 virus, which appears to have originated in bats, then rapidly accommodated to human hosts [13].
T33 2755-2922 Sentence denotes Coronaviruses are single-stranded, positive-sense, enveloped RNA viruses in the nidovirales order that are categorized into four genera: alpha, beta, gamma, and delta.
T34 2923-3004 Sentence denotes The SARS-CoV-2 virus associated with the COVID-19 epidemic is a beta-coronavirus.
T35 3005-3125 Sentence denotes Seven known coronaviruses affect humans: HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, MERS-CoV, SARS-CoV, and SARS-CoV-2.
T36 3126-3170 Sentence denotes Many coronavirus-related illnesses are mild.
T37 3171-3266 Sentence denotes In fact, coronaviruses were first studied in the 1960s as being agents of the common cold [14].
T38 3267-3411 Sentence denotes Nevertheless, of these viruses, only MERS-CoV, SARS-CoV, and SARS-CoV-2 are associated with potentially severe symptoms and fatal outcomes [15].
T39 3412-3504 Sentence denotes Once in the body, viruses may invade the CNS through hematogenous spread defined by viremia.
T40 3505-3734 Sentence denotes Viruses may also enter the CNS through retrograde neuronal dissemination, which occurs when the virus infects peripheral neurons, subsequently spreading to the spine and brain by way of the existing neuronal transport mechanisms.
T41 3735-3936 Sentence denotes It is the aim of this narrative review to describe what is known about neurological manifestations of SARS, MERS, and COVID-19, with special emphasis on reports about neurological symptoms in COVID-19.