Id |
Subject |
Object |
Predicate |
Lexical cue |
T93 |
0-33 |
Sentence |
denotes |
Severe acute respiratory syndrome |
T94 |
34-107 |
Sentence |
denotes |
SARS broke out in Hong Kong, Taiwan, Canada, and other locations in 2003. |
T95 |
108-206 |
Sentence |
denotes |
It has been reported to be associated with encephalitis, ischemic stroke, and polyneuropathy [35]. |
T96 |
207-291 |
Sentence |
denotes |
Seizures have been mentioned as the first symptom of SARS-related encephalitis [36]. |
T97 |
292-431 |
Sentence |
denotes |
In a necropsy study of eight patients who died of SARS, there was evidence of SARS-CoV infection in the brain cortex and hypothalamus [37]. |
T98 |
432-569 |
Sentence |
denotes |
Particles from the SARS-CoV virus have been found in the brains of patients infected with SARS, most frequently in brain neurons [37–39]. |
T99 |
570-715 |
Sentence |
denotes |
Murine studies found that intranasal injections of both MERS-CoV and SARS-CoV could enter the brain, presumably via the olfactory nerves [40,41]. |
T100 |
716-855 |
Sentence |
denotes |
Among the areas of the brain infected, the brain stem was a primary, but not exclusive, target for both MERS-CoV [41] and SARS-CoV [40,42]. |
T101 |
856-923 |
Sentence |
denotes |
Neurological sequelae of SARS have been only sporadically reported. |
T102 |
924-1164 |
Sentence |
denotes |
Acute olfactory neuropathy has been reported in a case study of a 27-year-old female SARS patient who was diagnosed with SARS in 2003, hospitalized, and recovered with combination therapy of antiviral therapy (ribivarin plus steroids) [43]. |
T103 |
1165-1226 |
Sentence |
denotes |
Fever persisted for about three weeks from onset of symptoms. |
T104 |
1227-1353 |
Sentence |
denotes |
She was discharged from the hospital at around the same time she reported the paroxysmal bilateral loss of her sense of smell. |
T105 |
1354-1538 |
Sentence |
denotes |
An otolaryngologic examination, biochemistry tests, and subsequent magnetic resonance imaging scans showed nothing unusual with no lesions that might account for her loss of olfaction. |
T106 |
1539-1632 |
Sentence |
denotes |
Now 2 years after her recovery from SARS, she still has not regained her sense of smell [43]. |
T107 |
1633-1844 |
Sentence |
denotes |
The common causes of anosmia include structural defects in the nasal cavity or sinuses, head injury, brain trauma, brain lesions, or drug-induced loss of olfaction, and in her case, these could all be ruled out. |
T108 |
1845-1940 |
Sentence |
denotes |
It was postulated that her anosmia was a coronavirus-induced form of olfactory neuropathy [43]. |
T109 |
1941-2009 |
Sentence |
denotes |
Neuromuscular symptoms associated with SARS have also been reported. |
T110 |
2010-2109 |
Sentence |
denotes |
A 51-year-old woman in Taiwan developed probable SARS shortly after her husband was diagnosed [44]. |
T111 |
2110-2288 |
Sentence |
denotes |
She was hospitalized and intubated and had no evidence of respiratory syncytial virus; however, a bone-marrow biopsy showed evidence of infection-related hemophagocytic syndrome. |
T112 |
2289-2415 |
Sentence |
denotes |
Her condition gradually improved and she was extubated, but she complained of weakness, numbness, and paresthesia in her legs. |
T113 |
2416-2606 |
Sentence |
denotes |
Ten days after extubation, a neurological examination showed good mental clarity with intact cranial nerves, but symmetric loss of muscle strength in her legs and mild weakness in the hands. |
T114 |
2607-2784 |
Sentence |
denotes |
These conditions improved slowly and two months later, a neurological examination reported only mild loss of leg strength and slight numbness in the toes of her right foot [44]. |
T115 |
2785-2959 |
Sentence |
denotes |
A case report from Hong Kong describes a 59-year-old woman with severe SARS who developed status epilepticus; evidence of the virus was found in her cerebrospinal fluid [45]. |
T116 |
2960-3117 |
Sentence |
denotes |
Another case report describes a pregnant patient with SARS who experienced a generalized convulsion with suspected nervous system invasion by the virus [46]. |
T117 |
3118-3300 |
Sentence |
denotes |
The neurological manifestations observed in SARS include peripheral axonal neuropathy and elevated muscle enzymes, which might be caused by extensive virus-driven vasculitis [38,47]. |
T118 |
3301-3409 |
Sentence |
denotes |
These were considered to be polyneuropathic and/or myopathic symptoms associated with critical illness [47]. |