PMC:7799377 / 14168-17577 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T93 0-33 Sentence denotes Severe acute respiratory syndrome
T94 34-107 Sentence denotes SARS broke out in Hong Kong, Taiwan, Canada, and other locations in 2003.
T95 108-206 Sentence denotes It has been reported to be associated with encephalitis, ischemic stroke, and polyneuropathy [35].
T96 207-291 Sentence denotes Seizures have been mentioned as the first symptom of SARS-related encephalitis [36].
T97 292-431 Sentence denotes In a necropsy study of eight patients who died of SARS, there was evidence of SARS-CoV infection in the brain cortex and hypothalamus [37].
T98 432-569 Sentence denotes Particles from the SARS-CoV virus have been found in the brains of patients infected with SARS, most frequently in brain neurons [37–39].
T99 570-715 Sentence denotes Murine studies found that intranasal injections of both MERS-CoV and SARS-CoV could enter the brain, presumably via the olfactory nerves [40,41].
T100 716-855 Sentence denotes Among the areas of the brain infected, the brain stem was a primary, but not exclusive, target for both MERS-CoV [41] and SARS-CoV [40,42].
T101 856-923 Sentence denotes Neurological sequelae of SARS have been only sporadically reported.
T102 924-1164 Sentence denotes Acute olfactory neuropathy has been reported in a case study of a 27-year-old female SARS patient who was diagnosed with SARS in 2003, hospitalized, and recovered with combination therapy of antiviral therapy (ribivarin plus steroids) [43].
T103 1165-1226 Sentence denotes Fever persisted for about three weeks from onset of symptoms.
T104 1227-1353 Sentence denotes She was discharged from the hospital at around the same time she reported the paroxysmal bilateral loss of her sense of smell.
T105 1354-1538 Sentence denotes An otolaryngologic examination, biochemistry tests, and subsequent magnetic resonance imaging scans showed nothing unusual with no lesions that might account for her loss of olfaction.
T106 1539-1632 Sentence denotes Now 2 years after her recovery from SARS, she still has not regained her sense of smell [43].
T107 1633-1844 Sentence denotes The common causes of anosmia include structural defects in the nasal cavity or sinuses, head injury, brain trauma, brain lesions, or drug-induced loss of olfaction, and in her case, these could all be ruled out.
T108 1845-1940 Sentence denotes It was postulated that her anosmia was a coronavirus-induced form of olfactory neuropathy [43].
T109 1941-2009 Sentence denotes Neuromuscular symptoms associated with SARS have also been reported.
T110 2010-2109 Sentence denotes A 51-year-old woman in Taiwan developed probable SARS shortly after her husband was diagnosed [44].
T111 2110-2288 Sentence denotes She was hospitalized and intubated and had no evidence of respiratory syncytial virus; however, a bone-marrow biopsy showed evidence of infection-related hemophagocytic syndrome.
T112 2289-2415 Sentence denotes Her condition gradually improved and she was extubated, but she complained of weakness, numbness, and paresthesia in her legs.
T113 2416-2606 Sentence denotes Ten days after extubation, a neurological examination showed good mental clarity with intact cranial nerves, but symmetric loss of muscle strength in her legs and mild weakness in the hands.
T114 2607-2784 Sentence denotes These conditions improved slowly and two months later, a neurological examination reported only mild loss of leg strength and slight numbness in the toes of her right foot [44].
T115 2785-2959 Sentence denotes A case report from Hong Kong describes a 59-year-old woman with severe SARS who developed status epilepticus; evidence of the virus was found in her cerebrospinal fluid [45].
T116 2960-3117 Sentence denotes Another case report describes a pregnant patient with SARS who experienced a generalized convulsion with suspected nervous system invasion by the virus [46].
T117 3118-3300 Sentence denotes The neurological manifestations observed in SARS include peripheral axonal neuropathy and elevated muscle enzymes, which might be caused by extensive virus-driven vasculitis [38,47].
T118 3301-3409 Sentence denotes These were considered to be polyneuropathic and/or myopathic symptoms associated with critical illness [47].