PMC:7799377 / 11344-14166 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T74 0-35 Sentence denotes Middle eastern respiratory syndrome
T75 36-189 Sentence denotes MERS was first identified in September 2012 in a 60-year-old man in Jeddah, Saudi Arabia, who presented with pneumonia complicated by renal failure [31].
T76 190-351 Sentence denotes Sporadic cases were reported outside of the Middle East up until 2015, when an outbreak in South Korea occurred with 186 confirmed infections and 38 deaths [32].
T77 352-493 Sentence denotes MERS has established associations with encephalomyelitis, vasculitis, Guillain-Barré syndrome (GBS), and encephalitis of the brain stem [21].
T78 494-647 Sentence denotes The clinical course of MERS ranges from asymptomatic cases (about 4%) to severe pneumonia with multiorgan involvement and negative patient outcomes [15].
T79 648-818 Sentence denotes While pulmonary, gastrointestinal, renal, and hematological complications have been reported in MERS patients, there are fewer reports of neurological complications [15].
T80 819-911 Sentence denotes In fact, the MERS-CoV virus has never been isolated from neural tissue in human beings [28].
T81 912-1134 Sentence denotes In a study of 737 hospitalized MERS patients in South Korea, the most commonly reported symptoms were respiratory symptoms (13.6%), fever (11.1%), fatigue (11.1%), myalgia (9.2%), and gastrointestinal symptoms (7.5%) [32].
T82 1135-1271 Sentence denotes In a study of 23 MERS patients from South Korea, 17.4% experienced neurological symptoms either during or following MERS treatment [33].
T83 1272-1384 Sentence denotes These neurological complications occurred about two to three weeks after the onset of respiratory symptoms [33].
T84 1385-1507 Sentence denotes A study from Saudi Arabia (n = 70) reported that 24.7% of MERS patients experienced confusion and 8.6% had a seizure [34].
T85 1508-1609 Sentence denotes In this study, fever was present in 61.4% of patients, dyspnea occurred in 60%, an 54.3% had a cough.
T86 1610-1749 Sentence denotes MERS symptoms were typically severe with 70% of those hospitalized in this study requiring intensive care and 60% of this cohort died [34].
T87 1750-1927 Sentence denotes The literature reports a fatal case of a 34-year-old woman with diabetes hospitalized for MERS, who two weeks after diagnosis developed a headache with nausea and vomiting [15].
T88 1928-2170 Sentence denotes An urgent computed tomography scan showed right frontal lobe intracerebral hemorrhage with massive brain edema; laboratory findings showed disseminated intravascular coagulation, including thrombocytopenia and a prolonged coagulation profile.
T89 2171-2353 Sentence denotes In another case, a 28-year-old man was hospitalized in the intensive care unit for MERS complicated by bacterial pneumonia and had to be put on a ventilator for respiratory distress.
T90 2354-2482 Sentence denotes Unfortunately, after initial improvement, he reported weakness and tingling in his legs that made it impossible for him to walk.
T91 2483-2650 Sentence denotes Using neuroimaging scans, cerebrospinal fluid analysis, nerve conduction velocity studies, and spinal imaging, a diagnosis was made of critical-illness polyneuropathy.
T92 2651-2822 Sentence denotes He was treated with intravenous (IV) immunoglobulin 400 mg/kg daily for five days and was discharged in 40 days; gradual improvement was noted over the next 6 months [15].