LitCovid-sentences  

PMC:7796072 / 10150-12840 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T68 0-127 Sentence denotes The genetic and molecular mechanisms of this hypothesized protection are as yet elusive, but biological evidence is suggestive.
T69 128-254 Sentence denotes Hemoglobinopathy-induced red blood cell structural modifications hinder invasion, growth, and migration of plasmodium [42,45].
T70 255-398 Sentence denotes Recent studies in thalassemias have pointed to the involvement of microRNAs (miRNAs) in malarial pathogenesis and anti-plasmodial defense [45].
T71 399-662 Sentence denotes MicroRNAs (miRNAs) are 18–25 nucleotide long, small, non-coding RNA molecules whose production is strictly regulated and abundant in all human cells [46]. miRNAs can downregulate gene expression in translational repression and target around 60% of all genes [46].
T72 663-787 Sentence denotes They exhibit decisive regulatory functions associated with a variety of disease processes, including microbial defense [46].
T73 788-1017 Sentence denotes In dengue virus infection, which is perennially endemic in SE Asia, red blood cell precursors in Thai carriers of thalassemia and HbE trait were significantly less susceptible to the dengue virus compared to normal controls [43].
T74 1018-1131 Sentence denotes This was the first report documenting an antiviral effect of the HbE trait akin to its anti-malarial effect [43].
T75 1132-1430 Sentence denotes A large number of miRNAs have also been implicated in dengue virus defense via structural protein integrity alterations inhibiting access of viral replication machinery to the cytoskeletal apparatus (miR-223) [47], but also through modulations of the host immune interferon response (miR-155) [48].
T76 1431-1572 Sentence denotes Remarkably, increased levels of the latter molecule have been reported in β-thalassemia/HbE patients and linked to BACH1 downregulation [49].
T77 1573-1783 Sentence denotes The same miRNA molecule was also reported to inhibit dengue virus replication by inducing antiviral interferon responses through the same BACH1 pathway downregulation and heme oxygenase-1-(HO-1) induction [48].
T78 1784-2024 Sentence denotes Rare putative loss-of-function variants of X-chromosomal toll-like receptor 7 (TLR7) causing immunological defects in type I and II interferon production have been very recently identified in 4 young male patients with severe COVID-19 [50].
T79 2025-2214 Sentence denotes Type I and II interferon (IFN) responses have been implicated in the initiation of an early immune response to clear the SARS-CoV-2 coronavirus and prevent the development of COVID-19 [50].
T80 2215-2396 Sentence denotes Moreover, the addition of interferon beta-1b to other antivirals in the clinical setting was also more effective in treating COVID-19 patients and rendering them noninfectious [51].
T81 2397-2580 Sentence denotes HO-1 pathway derangements have been implicated in severe COVID-19 infection [52] and in causing exhaustion of hematopoietic stem cells, possibly leading to immune system failure [53].
T82 2581-2690 Sentence denotes Similar structural and molecular mechanisms might be operative in immune effector cells of HbE heterozygotes.