PMC:7796052 / 7114-7734 2 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T48 | 0-357 | Sentence | denotes | As can be seen in Figure 1a, raloxifene antagonizes BK with an IC50 ~16 µM with an apparent dissociation constant KB = 1.8 µM, computed using the modified Cheng Prusoff equation [32]:KB=IC501+AEC50 where, IC50 = 16 µM corresponds to raloxifene and EC50 = 2.4 pM corresponds to BK, and A = 0.03 nM is the concentration of BK that was used in the experiments. |
| T49 | 358-453 | Sentence | denotes | We also tested its activity as an agonist on CHO cells stably transfected with the B2 receptor. |
| T50 | 454-620 | Sentence | denotes | Present results also showed (Figure 1b) that the compound exhibited a partial agonistic profile, with a maximum effect of 20% of BK that was achieved at around 20 µM. |