Id |
Subject |
Object |
Predicate |
Lexical cue |
T23 |
0-205 |
Sentence |
denotes |
Nowadays, icatibant is the only BK antagonist approved as therapeutic agent for the treatment of hereditary angioedema [19], in spite of the number of selective BK ligands described in the literature [20]. |
T24 |
206-378 |
Sentence |
denotes |
The discovery of the bradykinin hypothesis prompted the launch of an ongoing clinical trial to assess the benefits of icatibant for the treatment of covid-19 patients [21]. |
T25 |
379-569 |
Sentence |
denotes |
In other to swiftly test the efficacy of alternative BK antagonists with diverse pharmacological profiles for the treatment of Covid-19, drug repurposing represents a valuable strategy [22]. |
T26 |
570-740 |
Sentence |
denotes |
To this aim, we recently carried out a virtual screening study on the DrugBank database [23] aimed at identifying BK ligands among drugs already approved by the FDA [24]. |
T27 |
741-931 |
Sentence |
denotes |
The study was carried out using four points common to the pharmacophores derived for the B1 and B2 bradykinin receptors recently reported that were used as queries for the search [25,26,27]. |
T28 |
932-1056 |
Sentence |
denotes |
Hits identified were subsequently subjected to a docking study using the Molecular Operating Environment (MOE) program [28]. |