PMC:7796041 / 10200-13764 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T89 0-4 Sentence denotes 3.1.
T90 5-60 Sentence denotes Baseline Characteristics and Outcomes in Overall Cohort
T91 61-151 Sentence denotes Median age was 64.1 ± 16.7 years, and the majority of patients were male (n = 108, 65.1%).
T92 152-230 Sentence denotes Arterial hypertension constituted the most common risk factor (n = 83, 50.0%).
T93 231-384 Sentence denotes Cardiovascular disease was present in 18.1% (n = 30), cardiomyopathy in 3.0% (n = 5), diabetes mellitus in 17.5% (n = 29), and obesity in 21.7% (n = 36).
T94 385-746 Sentence denotes Other relevant comorbidities comprised pulmonary disease (e.g., chronic obstructive pulmonary disease, pulmonary fibrosis) in 14.5% (n = 24), previous or active cancer disease in 8.4% (n = 14), and conditions associated with immunodeficiency (e.g., due to chronic immunosuppression therapy after organ transplantation or hematological disease) in 8.4% (n = 14).
T95 747-841 Sentence denotes Information on left ventricular ejection fraction (LVEF) was available in 44 patients (26.5%).
T96 842-886 Sentence denotes Mean LVEF in this subgroup was 53.0 ± 12.3%.
T97 887-951 Sentence denotes In three patients a cardiac pacemaker had been implanted (1.8%).
T98 952-1033 Sentence denotes Implanted cardioverter-defibrillators (ICDs) were present in two patients (1.2%).
T99 1034-1136 Sentence denotes Seven patients (4.2%) presented with syncope in association with COVID-19 prior to hospital admission.
T100 1137-1191 Sentence denotes Median duration of hospitalization was 10.5 days (P25:
T101 1192-1204 Sentence denotes 5 days; P75:
T102 1205-1223 Sentence denotes 22 days, n = 154).
T103 1224-1368 Sentence denotes In 12 patients, data on duration of hospitalization could not be assessed due to transfer to a different center not participating in this study.
T104 1369-1564 Sentence denotes The majority of patients required oxygen therapy in the course of hospital stay, and over a third of all patients was admitted to intensive care (ICU) or intermediate care units (IMC) (Figure 1).
T105 1565-1616 Sentence denotes Median duration of ICU/IMC-therapy was 8 days (P25:
T106 1617-1629 Sentence denotes 4 days; P75:
T107 1630-1641 Sentence denotes 22.5 days).
T108 1642-1881 Sentence denotes High-flow oxygen therapy and/or non-invasive ventilation (NIV) by continuous positive airway pressure (CPAP) was necessary in 39 patients (23.5%), and pharmacological circulatory support by vasopressors was provided in 30 patients (18.1%).
T109 1882-1983 Sentence denotes Thirty-seven patients (22.3%) received mechanical ventilation with a median duration of 17 days (P25:
T110 1984-1998 Sentence denotes 7.5 days; P75:
T111 1999-2008 Sentence denotes 26 days).
T112 2009-2101 Sentence denotes Of these, six patients had to be re-intubated after initially successful weaning (Figure 1).
T113 2102-2239 Sentence denotes Only a minority of patients underwent extracorporeal membrane oxygenation (ECMO) or in-hospital cardiopulmonary resuscitation (Figure 1).
T114 2240-2400 Sentence denotes With respect to cardiovascular events, myocarditis was suspected in one patient based on cardiac biomarker-kinetics and mildly reduced LVEF in echocardiography.
T115 2401-2471 Sentence denotes This patient died due to respiratory failure during the hospital stay.
T116 2472-2546 Sentence denotes However, the diagnosis of myocarditis could not be confirmed upon autopsy.
T117 2547-2633 Sentence denotes Four patients were diagnosed with myocardial infarction (2.4%) during hospitalization.
T118 2634-2867 Sentence denotes Percutaneous coronary intervention (PCI) was performed in two cases, of which one patient presented with ST segment elevation myocardial infarction (STEMI) and one patient with non-ST segment elevation myocardial infarction (NSTEMI).
T119 2868-3062 Sentence denotes In the other two cases diagnosed with NSTEMI, medical therapy alone was preferred due to clinical instability with predominant respiratory symptoms and stable echocardiographic and ECG findings.
T120 3063-3160 Sentence denotes One patient with NSTEMI and PCI died in the course of hospitalization due to mesenteric ischemia.
T121 3161-3237 Sentence denotes Stroke or transient ischemic attack (TIA) was seen in three patients (1.8%).
T122 3238-3388 Sentence denotes Twenty-six patients died during hospitalization, predominantly due to respiratory failure (n = 20, 76.9%) or other non-cardiac reasons (n = 5, 19.2%).
T123 3389-3564 Sentence denotes Only one death was attributed to cardiac causes (3.8%), i.e., cardiac circulatory failure in a mechanically ventilated patient with pre-existent severe cardiovascular disease.