PMC:7795966 / 32791-34535 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T234 0-2 Sentence denotes 5.
T235 3-26 Sentence denotes Summary and Conclusions
T236 27-142 Sentence denotes We identified and analyzed nine studies that reported information about MetHb and COHb values of COVID-19 patients.
T237 143-281 Sentence denotes 86% (6/7) studies reported an increased MetHb concentration above the normal reference range, and one study did not find such an increase.
T238 282-369 Sentence denotes Regarding COHb, 67% (2/3) studies reported an increase, and one found no elevated COHb.
T239 370-619 Sentence denotes As highlighted by the observations of Palmer et al. [22] and Paccaud et al. [24], the time of MetHb and COHb measurement during the course of the disease is critical, since MetHb and COHb seem to generally increase in hospitalized COVID-19 patients.
T240 620-808 Sentence denotes The type of medical treatment is also of importance since some drugs currently used to treat COVID-19 have a high oxidizing potential provoking methemoglobinemia and carboxyhemoglobinemia.
T241 809-986 Sentence denotes Monitoring of MetHb and COHb values routinely, and if possible, continuously with non-invasive pulse CO-oximeters, seems to be warranted for optimal COVID-19 disease monitoring.
T242 987-1138 Sentence denotes The tHb, MetHb and COHb concentration in the blood is also relevant for a correct interpretation of SpO2 values measured with fingertip pulse oximetry.
T243 1139-1264 Sentence denotes Future studies should investigate in detail the link between MetHb/COHb levels in COVID-19 patients and the clinical outcome.
T244 1265-1412 Sentence denotes As both values were found to be independently related to mortality in critically ill patients [77], the assessment of both parameters is necessary.
T245 1413-1534 Sentence denotes In conclusion, MetHb and COHb seem to be elevated in COVID-19 patients, with a dynamic following the disease progression.
T246 1535-1744 Sentence denotes MetHb and COHb measurements should be regularly assessed in COVID-19 patients, for example with blood gas analysis (which includes a CO-oximetry module), conventional CO-oximeters or by continuous CO-oximetry.