Id |
Subject |
Object |
Predicate |
Lexical cue |
T234 |
0-2 |
Sentence |
denotes |
5. |
T235 |
3-26 |
Sentence |
denotes |
Summary and Conclusions |
T236 |
27-142 |
Sentence |
denotes |
We identified and analyzed nine studies that reported information about MetHb and COHb values of COVID-19 patients. |
T237 |
143-281 |
Sentence |
denotes |
86% (6/7) studies reported an increased MetHb concentration above the normal reference range, and one study did not find such an increase. |
T238 |
282-369 |
Sentence |
denotes |
Regarding COHb, 67% (2/3) studies reported an increase, and one found no elevated COHb. |
T239 |
370-619 |
Sentence |
denotes |
As highlighted by the observations of Palmer et al. [22] and Paccaud et al. [24], the time of MetHb and COHb measurement during the course of the disease is critical, since MetHb and COHb seem to generally increase in hospitalized COVID-19 patients. |
T240 |
620-808 |
Sentence |
denotes |
The type of medical treatment is also of importance since some drugs currently used to treat COVID-19 have a high oxidizing potential provoking methemoglobinemia and carboxyhemoglobinemia. |
T241 |
809-986 |
Sentence |
denotes |
Monitoring of MetHb and COHb values routinely, and if possible, continuously with non-invasive pulse CO-oximeters, seems to be warranted for optimal COVID-19 disease monitoring. |
T242 |
987-1138 |
Sentence |
denotes |
The tHb, MetHb and COHb concentration in the blood is also relevant for a correct interpretation of SpO2 values measured with fingertip pulse oximetry. |
T243 |
1139-1264 |
Sentence |
denotes |
Future studies should investigate in detail the link between MetHb/COHb levels in COVID-19 patients and the clinical outcome. |
T244 |
1265-1412 |
Sentence |
denotes |
As both values were found to be independently related to mortality in critically ill patients [77], the assessment of both parameters is necessary. |
T245 |
1413-1534 |
Sentence |
denotes |
In conclusion, MetHb and COHb seem to be elevated in COVID-19 patients, with a dynamic following the disease progression. |
T246 |
1535-1744 |
Sentence |
denotes |
MetHb and COHb measurements should be regularly assessed in COVID-19 patients, for example with blood gas analysis (which includes a CO-oximetry module), conventional CO-oximeters or by continuous CO-oximetry. |