Id |
Subject |
Object |
Predicate |
Lexical cue |
T209 |
0-15 |
Sentence |
denotes |
Acknowledgments |
T210 |
16-229 |
Sentence |
denotes |
The authors wish to thank Nicole Däschlein, Hyun-Jin Kim and Rebecca Walser, all at XL-protein, for help in gene cloning and western blotting and Corinna Brandt and Stefan Achatz at TUM for performing MS analyses. |
T211 |
230-353 |
Sentence |
denotes |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
T212 |
355-375 |
Sentence |
denotes |
Author Contributions |
T213 |
376-472 |
Sentence |
denotes |
Conceptualization, U.B. and A.S.; experimental work, U.B.; manuscript preparation, U.B. and A.S. |
T214 |
473-549 |
Sentence |
denotes |
All authors have read and agreed to the published version of the manuscript. |
T215 |
551-558 |
Sentence |
denotes |
Funding |
T216 |
559-602 |
Sentence |
denotes |
This research received no external funding. |
T217 |
604-640 |
Sentence |
denotes |
Institutional Review Board Statement |
T218 |
641-779 |
Sentence |
denotes |
The study was conducted in compliance with applicable animal welfare regulations (Institutional Animal Care and Use Committee approval No. |
T219 |
780-798 |
Sentence |
denotes |
2020_ATRC/5999_F). |
T220 |
799-1025 |
Sentence |
denotes |
The permission code for PK studies (PK, metabolism, and bioequivalence) was PE/EA/1374-5/2017 and the permitting authority was the Government Office for Pest County, Directorate of Food Chain Safety and Animal Health, Hungary. |
T221 |
1027-1053 |
Sentence |
denotes |
Informed Consent Statement |
T222 |
1054-1069 |
Sentence |
denotes |
Not applicable. |
T223 |
1071-1098 |
Sentence |
denotes |
Data Availability Statement |
T224 |
1099-1188 |
Sentence |
denotes |
The data presented in this study are available on request from the corresponding authors. |
T225 |
1190-1211 |
Sentence |
denotes |
Conflicts of Interest |
T226 |
1212-1278 |
Sentence |
denotes |
U.B. and A.S. are co-founders and shareholders of XL-protein GmbH. |
T227 |
1279-1292 |
Sentence |
denotes |
Abbreviations |
T228 |
1293-1312 |
Sentence |
denotes |
AEX Anion exchange |
T229 |
1313-1337 |
Sentence |
denotes |
AP Alkaline phosphatase |
T230 |
1338-1376 |
Sentence |
denotes |
aTc Anhydrotetracycline hydrochloride |
T231 |
1377-1400 |
Sentence |
denotes |
AUC Area und the curve |
T232 |
1401-1443 |
Sentence |
denotes |
BCIP 5-Bromo-4-chloro-3-indoxyl phosphate |
T233 |
1444-1469 |
Sentence |
denotes |
BSA Bovine serum albumin |
T234 |
1470-1490 |
Sentence |
denotes |
CEX Cation exchange |
T235 |
1491-1504 |
Sentence |
denotes |
CL Clearance |
T236 |
1505-1548 |
Sentence |
denotes |
Cmax Maximum (or peak) serum concentration |
T237 |
1549-1580 |
Sentence |
denotes |
CNP C-type natriuretic peptide |
T238 |
1581-1642 |
Sentence |
denotes |
CORYNEX Corynebacterium glutamicum protein expression system |
T239 |
1643-1700 |
Sentence |
denotes |
COVID-19 Severe acute respiratory syndrome coronavirus 2 |
T240 |
1701-1752 |
Sentence |
denotes |
CTLA-4 Cytotoxic T-lymphocyte-associated protein 4 |
T241 |
1753-1770 |
Sentence |
denotes |
CV Column volume |
T242 |
1771-1791 |
Sentence |
denotes |
DCs Dendritic cells |
T243 |
1792-1822 |
Sentence |
denotes |
DPP-IV Dipeptidyl peptidase-4 |
T244 |
1823-1863 |
Sentence |
denotes |
ELISA Enzyme-linked immunosorbent assay |
T245 |
1864-1900 |
Sentence |
denotes |
ESETEC E. coli secretion technology |
T246 |
1901-1950 |
Sentence |
denotes |
ESI-MS Electrospray ionization mass spectrometry |
T247 |
1951-1991 |
Sentence |
denotes |
FPLC Fast protein liquid chromatography |
T248 |
1992-2005 |
Sentence |
denotes |
GCC Glucagon |
T249 |
2006-2055 |
Sentence |
denotes |
GIP Glucose-dependent insulinotropic polypeptide |
T250 |
2056-2086 |
Sentence |
denotes |
GLP-1 Glucagon-like peptide 1 |
T251 |
2087-2143 |
Sentence |
denotes |
GM-CSF Granulocyte-macrophage colony-stimulating factor |
T252 |
2144-2181 |
Sentence |
denotes |
GSH γ-L-Glutamyl-L-cysteinyl-glycine |
T253 |
2182-2204 |
Sentence |
denotes |
HBV Hepatitis B virus |
T254 |
2205-2227 |
Sentence |
denotes |
HCV Hepatitis C virus |
T255 |
2228-2253 |
Sentence |
denotes |
hGH Human growth hormone |
T256 |
2254-2280 |
Sentence |
denotes |
hIFN-α Human interferon 1 |
T257 |
2281-2318 |
Sentence |
denotes |
HIV-1 Human immunodeficiency virus I |
T258 |
2319-2373 |
Sentence |
denotes |
iRGD Internalizing arginylglycylaspartic acid peptide |
T259 |
2374-2428 |
Sentence |
denotes |
K3-EDTA Tri-potassium ethylenediaminetetraacetic acid |
T260 |
2429-2466 |
Sentence |
denotes |
MHC Major histocompatibility complex |
T261 |
2467-2509 |
Sentence |
denotes |
MOPS 3-(N-morpholino)propanesulfonic acid |
T262 |
2510-2537 |
Sentence |
denotes |
NBT Nitro blue tetrazolium |
T263 |
2538-2567 |
Sentence |
denotes |
OD Optical density at 550 nm |
T264 |
2568-2602 |
Sentence |
denotes |
PAS Proline/alanine-rich sequence |
T265 |
2603-2638 |
Sentence |
denotes |
PAS-Tα1 N-terminally PASylated Tα1 |
T266 |
2639-2669 |
Sentence |
denotes |
PBS Phosphate-buffered saline |
T267 |
2670-2690 |
Sentence |
denotes |
PD Pharmacodynamics |
T268 |
2691-2715 |
Sentence |
denotes |
PEG Polyethylene glycol |
T269 |
2716-2720 |
Sentence |
denotes |
p.i. |
T270 |
2722-2736 |
Sentence |
denotes |
Post injection |
T271 |
2737-2757 |
Sentence |
denotes |
PK Pharmacokinetics |
T272 |
2758-2782 |
Sentence |
denotes |
ProTα Prothymosin alpha |
T273 |
2783-2807 |
Sentence |
denotes |
PTH Parathyroid hormone |
T274 |
2808-2840 |
Sentence |
denotes |
Q-TOF Quadrupole time of flight |
T275 |
2841-2867 |
Sentence |
denotes |
RBS Ribosome-binding site |
T276 |
2868-2899 |
Sentence |
denotes |
RGD Arginylglycylaspartic acid |
T277 |
2900-2954 |
Sentence |
denotes |
RimJ Ribosomal-protein-S5-alanine N-acetyltransferase |
T278 |
2955-2988 |
Sentence |
denotes |
RPC Reverse phase chromatography |
T279 |
2989-3009 |
Sentence |
denotes |
RT Room temperature |
T280 |
3010-3044 |
Sentence |
denotes |
SEC Size exclusion chromatography |
T281 |
3045-3112 |
Sentence |
denotes |
SDS-PAGE Sodium dodecyl sulfate polyacrylamide gel electrophoresis |
T282 |
3113-3145 |
Sentence |
denotes |
τ1/2α Half-life of distribution |
T283 |
3146-3174 |
Sentence |
denotes |
τ1/2β Elimination half-life |
T284 |
3175-3196 |
Sentence |
denotes |
Tα1 Thymosin alpha 1 |
T285 |
3197-3245 |
Sentence |
denotes |
Tα1-PAS C-terminally PASylated Thymosin alpha 1 |
T286 |
3246-3284 |
Sentence |
denotes |
tetp/o Tetracycline promoter/operator |
T287 |
3285-3302 |
Sentence |
denotes |
Th T helper cell |
T288 |
3303-3331 |
Sentence |
denotes |
tlpp Lipoprotein terminator |
T289 |
3332-3359 |
Sentence |
denotes |
TLR-2 Toll-like receptor 1 |
T290 |
3360-3387 |
Sentence |
denotes |
TLR-9 Toll-like receptor 2 |
T291 |
3388-3413 |
Sentence |
denotes |
TMAE Trimethylaminoethyl |
T292 |
3414-3438 |
Sentence |
denotes |
tmax Time to reach Cmax |