| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T182 |
0-4 |
Sentence |
denotes |
4.8. |
| T183 |
5-37 |
Sentence |
denotes |
Pharmacokinetic Analysis in Rats |
| T184 |
38-177 |
Sentence |
denotes |
A PK study in female Wistar rats at 8–9 weeks of age was conducted at the Aurigon Toxicological Research Center (ATRC, Dunakeszi, Hungary). |
| T185 |
178-319 |
Sentence |
denotes |
Up to 3 animals per cage were housed in a controlled environment at 22 ± 3 °C with a relative humidity of 50 ± 20%, 12 h light and 12 h dark. |
| T186 |
320-444 |
Sentence |
denotes |
Endotoxin-free purified Tα1-PAS (3.4 mg/kg) was administered subcutaneously via a single injection into the rat dorsal area. |
| T187 |
445-522 |
Sentence |
denotes |
Blood samples (100 µL) were taken from 5 animals each at various time points. |
| T188 |
523-782 |
Sentence |
denotes |
Following collection in tubes containing tri-potassium ethylenediaminetetraacetic acid (K3-EDTA) (Greiner Bio-One, Frickenhausen, Germany), samples were centrifuged at room temperature for 10 min (3000× g) and the resulting plasma was stored at −15 to −30 °C. |
| T189 |
783-1030 |
Sentence |
denotes |
Tα1-PAS in these samples was quantified using sandwich ELISA (see below) and the data were analyzed using the Phoenix WinNonlin 6.3 software (Certara, Princeton, NJ, USA) using a one-compartment model assuming 1st order absorption and elimination. |
