| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T114 |
0-214 |
Sentence |
denotes |
Moreover, a more continuous plasma level above the minimum effective dose due to slower clearance, as illustrated by the drastically increased AUC, should boost in vivo efficacy and open new treatment perspectives. |
| T115 |
215-603 |
Sentence |
denotes |
Especially in preclinical animal models, which typically suffer from a much quicker drug clearance compared to humans [37] owing to their smaller body size, a long-acting Tα1 should lead to more convincing pharmacodynamic (PD) effects and pave the way for biopharmaceutical development for novel indications such as cystic fibrosis [18], HIV-1 infection [58], sepsis [20], or cancer [59]. |
| T116 |
604-742 |
Sentence |
denotes |
For example, cancer studies have demonstrated that high doses of the conventional peptide are required to achieve antitumor activity [60]. |
