| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T109 |
0-295 |
Sentence |
denotes |
In comparison with other published approaches to prolong the circulation of Tα1, the measured terminal half-life of Tα1-PAS is even longer than the value of around 8.2 h reported for a corresponding PEGylated peptide after an intravenous injection into the tail vein of Sprague–Dawley rats [55]. |
| T110 |
296-436 |
Sentence |
denotes |
This modified Tα1 was prepared by chemically coupling a 5 kDa methoxypolyethylene glycol maleimide via an engineered N-terminal Cys residue. |
| T111 |
437-673 |
Sentence |
denotes |
Of note, according to the rules of allometric scaling, a much longer half-life in the range of several days can be expected for Tα1-PAS in humans [56,57], which would allow weekly dosing while achieving a lasting pharmacological effect. |
| T112 |
674-918 |
Sentence |
denotes |
According to the prescription information for Zadaxin™ to treat chronic hepatitis B, the recommended dose for the monotherapy, or the combination therapy with interferon, is a 1.6 mg subcutaneous injection twice weekly over 6 months (52 doses). |
| T113 |
919-1029 |
Sentence |
denotes |
Consequently, weekly or biweekly injections would considerably decrease patient burden and improve compliance. |
