LitCovid-sentences  

PMC:7784830 / 13947-21485 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T111 0-58 Sentence denotes ODFs as carriers for antiviral and immunity boosting herbs
T112 59-167 Sentence denotes WHO said ‘To date there is no specific medicine recommended to prevent or treat the novel coronavirus’ [68].
T113 168-357 Sentence denotes In view of the fact that there are no drugs and vaccines, that are approved, for treating COVID-19, many are turning toward herbal medicines that are either of the Indian or Chinese origin.
T114 358-478 Sentence denotes There are many herbs in Indian Ayurveda that have the potential for prophylaxis and treatment of corona virus infection.
T115 479-690 Sentence denotes For instance, Rastogi et al. reported a ‘pragmatic and plausible plan of action for Ayurvedic intervention’ of various Ayurvedic drugs that have the potential to be used in mild to severe COVID-19 symptoms [69].
T116 691-844 Sentence denotes Subjects who are not yet exposed and asymptomatic group can use Ayurvedic ‘Swarna Prashana’ and ‘Rasayana’ as potential immunity boosting agents [70–73].
T117 845-935 Sentence denotes This in combination with social distancing helps in preventing the spread of disease [74].
T118 936-1083 Sentence denotes Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy (AYUSH), Government of India recommends three immunity boosting measures.
T119 1084-1514 Sentence denotes First and foremost is taking 10 g of Chyavanprash every day (not suitable to formulate as ODFs due to its heavy dose), second: drinking golden milk (milk with turmeric) twice a day, and lastly drinking herbal tea or a drink prepared by boiling tulsi, cinnamon, black pepper, dry ginger and raisin taken either by adding jiggery (natural sweet) or lemon juice for taste, if required – to be taken once a day or twice in a day [75].
T120 1515-1658 Sentence denotes The Ministry of AYUSH has also confirmed that clinical trials are initiated on AYUSH-64, a polyherbal anti-malarial Ayurvedic formulation [76].
T121 1659-1843 Sentence denotes Indian Institute of Delhi in collaboration with National Institute of Advanced Industrial Science and Technology, Japan has reported the potential of Ashwagandha against COVID-19 [77].
T122 1844-2039 Sentence denotes CSIR (Council of Scientific and Industrial Research) in collaboration with Sun Pharma are working on a phytopharmaceutical composition that is found to be effective in treatment of COVID-19 [78].
T123 2040-2163 Sentence denotes Very recently, Sun Pharma received approval for clinical trials of AQCH from Drugs Controller General of India (DCGI) [79].
T124 2164-2443 Sentence denotes Chinese National Health Commission announced, dated 14 April 2020, three patented Chinese herbal drugs for treatment of COVID-19 which include namely: ‘Lianhuaqingwen capsules and Jinhuaqinggan granules for mild conditions, and Xuebijing (injectable) for severe conditions’ [80].
T125 2444-2582 Sentence denotes Luo et al. carried out an excellent review on Chinese herbal medicines that have the strong potential for usage in prevention of COVID-19.
T126 2583-2669 Sentence denotes They have also reported the highly used herbs for preventing COVID-19 infections [81].
T127 2670-2891 Sentence denotes A Korean company by name, Biostandard Inc, reported usage of fermented Isatidis Radix Extract and claim to be effective against corona virus infections and they have protected the same by a Korean patent application [82].
T128 2892-3034 Sentence denotes Few other companies/academic institutions that have patent protected herbal extracts effective in preventing COVID-19 are provided in Table 3.
T129 3035-3043 Sentence denotes Table 3.
T130 3045-3101 Sentence denotes Patent protected herbs for preventing/treating COVID-19.
T131 3102-3149 Sentence denotes Name of the player Drug name and details Ref.
T132 3150-3205 Sentence denotes Biostandard Inc Fermented Isatidis Radix Extract [82]
T133 3206-3354 Sentence denotes Bioniche Life Sciences Inc Pyranocoumarin enriched composition (free from furanocoumarins) obtained from Zanthoxylum americanum (Prickly Ash) [83]
T134 3355-3448 Sentence denotes The University of Hong Kong Baicalin – compound extracted from Scutellaria baicalensis [84]
T135 3449-3551 Sentence denotes Seoul National University Industry-Academic Cooperation Foundation Extract of Angelica dahurica [85]
T136 3552-3571 Sentence denotes Amazon Biotech Inc.
T137 3573-3908 Sentence denotes Herbal composition comprising ‘Boswellia carterii stem resin, Styrax benzoin stem resin, Cinnamomum zeylanicum bark, Curcuma zedoaria root, Syzygium aromaticum fruit, Nardostachys chinensis root, Betula alba bark, Impatiens balsamina bark, Costus spicatus root, Allium sativum bulb Cyperus rotundus root and Hyssopus officinalis’ [86]
T138 3909-3928 Sentence denotes Biopharmacopae Inc.
T139 3930-4296 Sentence denotes Extracts of ginger and/or goldenrod (Solidago) [87] A decoction of various Ayurvedic herbs namely: ‘Tinospora cordifolia, Zingiber officinale, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Adhatoda vasica, Andrographis paniculata, Swertia chirayita, Moringa oleifera, Triphala and Trikatu’ have broad antiviral activity and protease inhibitor activity [88–90].
T140 4297-4374 Sentence denotes This decoction could be very useful in COVID-19 patients who are quarantined.
T141 4375-4802 Sentence denotes Turning now to ODFs of herbal extracts, Cure pharmaceuticals published US patent on herbs ((agrimony, andrographis paniculata, bistort, fenugreek, ginger, myrrh, solanum, etc.) tree and plant extracts ((licorice, shitake, sarsaparilla, slippery elm, etc.), and essential oils (clove, camphor, cinnamon, lemon, spearmint, etc.) that are formulated as multilayered edible oral thin films for management of cough/Pharyngitis [91].
T142 4803-4868 Sentence denotes Table 4 provides a list of ODFs formulated using herbal extracts.
T143 4869-4981 Sentence denotes From the table, it is evident that solvent casting method is the most preferred method to fabricate herbal ODFs.
T144 4982-5139 Sentence denotes Zim laboratories limited, a leading Indian company in the domain of oral thin films has published a research article on oral dissolving films of ginger [21].
T145 5140-5220 Sentence denotes Visser et al. reported ODFs of five Indonesian medicinal plants extracts namely:
T146 5221-5382 Sentence denotes Lagerstroemia speciosa, Phyllanthus niruri, Cinnamomum burmannii, Zingiber officinale, and Phaleria macrocarpa [92] were prepared by solvent casting method [95].
T147 5383-5499 Sentence denotes Of these plant extracts, Phaleria macrocarpa and Zingiber officinale are associated with antiviral activity [96,97].
T148 5500-5608 Sentence denotes Song et al. evaluated antiviral activity of quercetin-7-glucoside isolated from Lagerstroemia speciosa [98].
T149 5609-5750 Sentence denotes Sri Wahyuni et al. reported antiviral activity of Phyllanthus niruri, particularly they reported its activity against hepatitis C virus [99].
T150 5751-5825 Sentence denotes Verma et al. reported ODFs of Piper betel and Foeniculum officinalis [93].
T151 5826-5913 Sentence denotes Foeniculum officinalis is reported to possess antiviral and antioxidant activity [100].
T152 5914-6010 Sentence denotes Similarly, Pawar and Butle reported ODFs of Allium sativum [94], a potent antiviral agent [101].
T153 6011-6019 Sentence denotes Table 4.
T154 6021-6056 Sentence denotes Antiviral herbs formulated as ODFs.
T155 6057-6239 Sentence denotes Name of the herb and technique employed, if any, to load to ODFs Reason for choosing/selecting the herb to formulate as an ODFs Polymer Plasticizer Method Key highlight(s) Ref.
T156 6240-6384 Sentence denotes Ginger extract Existing formulations (capsules and liquids) of ginger suffer with problems of wettability of contents and inaccuracy in dosing.
T157 6386-6613 Sentence denotes Hydroxypropyl methylcellulose (HPMC) or maltodextrin or pullulan Polyethylene glycol (PEG) Solvent casting method (SCM) HPMC based ODFs were found to be ideal with low disintegration time and stable at high temperature [21]
T158 6614-7004 Sentence denotes Indonesian herbal extracts of Phaleria macrocarpa and Zingiber officinale Selected based on the herbal extracts popularity, reproducibility and well established scientific support (clinical evidence) HPMC with carbomer 947p (or) hydroxypropyl cellulose (HPC) Glycerol SCM Stable ODFs were obtained and benzalkonium chloride was employed as a stabilizer and also for spreadability [92]
T159 7005-7172 Sentence denotes Foeniculum officinalis extract –a HPMC Glycerol SCM Employed super disintegrating agent (sodium starch glycollate) to achieve low disintegration time of ODF [93]
T160 7173-7265 Sentence denotes Garlic extract –a Hypromellose Glycerol SCM Menthol was used as a flavoring agent [94]
T161 7266-7283 Sentence denotes a Nothing found.
T162 7284-7379 Sentence denotes Generally speaking, ODFs are well known to act as carriers for various herbal extracts [18–21].
T163 7380-7538 Sentence denotes But, from the above explanation, it is particularly evident that they have the potential to act as carriers to aid in the delivery of various antiviral herbs.