PMC:7784828 / 13076-14239 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T114 0-4 Sentence denotes 3.2.
T115 6-38 Sentence denotes Limitations and more of the same
T116 39-173 Sentence denotes A large number of drugs approved by the FDA in the past 10 years are new formulations of existing drugs referred to as ‘me too drugs’.
T117 174-363 Sentence denotes While in some cases these drugs have offered some improvements over older versions, in many cases improvements remain marginal with slight changes in side effects or activity profiles [34].
T118 364-511 Sentence denotes Since these drugs have identical mechanism of action to older versions their innovative value and overall benefit is oftentimes insignificant [35].
T119 512-624 Sentence denotes Additionally, the molecular effects of several marketed drugs remain unknown despite their proven effectiveness.
T120 625-765 Sentence denotes For example, acetaminophen is used by millions to treat mild to moderate pain while lithium is a first-line treatment for biopolar disorder.
T121 766-844 Sentence denotes Yet the exact molecular target and mechanism of action remain unknown [36,37].
T122 845-981 Sentence denotes Many diseases particularly those affect the nervous system like Alzheimer, Parkinson’s, and depression lack accurate biomarkers [38,39].
T123 982-1163 Sentence denotes While progress is being made, the lack of reliable biomarkers remains another impediment for the accurate diagnosis, prognosis and effective drug development against these diseases.