LitCovid-sentences  

PMC:7784824 / 1891-7434 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T27 0-10 Sentence denotes Background
T28 11-113 Sentence denotes In December 2019, several cases of an unidentified pneumonia occurred in the province of Hubei, China.
T29 114-250 Sentence denotes With the use of next-generation sequencing, the Wuhan Institute of Virology identified a new coronavirus as the etiological agent [1,2].
T30 251-380 Sentence denotes This new virus, which belongs to the genus betacoronavirus, was initially acknowledged as novel coronavirus 2019 (2019-nCOV) [3].
T31 381-558 Sentence denotes On 11 February 2020, the virus was officially renamed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses [4].
T32 559-714 Sentence denotes Since then the virus has rapidly spread and on the 18th of July 2020, over 14 million confirmed cases and 600 000 direct casualties have been reported [5].
T33 715-880 Sentence denotes So far, implementation of strict quarantine measures have contained further exponential spreading of the virus in Europe and have flattened the first epidemic curve.
T34 881-1051 Sentence denotes Considering the extent of the pandemic, its socio-economic impact, and the effect on healthcare systems worldwide, there is a high need to extend the diagnostic capacity.
T35 1052-1227 Sentence denotes So far, the gold standard for the diagnosis of SARS-CoV-2, implemented at the start of the outbreak, is real-time reverse transcriptase polymerase chain reaction (RT-PCR) [6].
T36 1228-1378 Sentence denotes In contrast with a high specificity up to 98.8% [7], RT-PCR suffers from a rather long turnaround time when performed in batch testing (2 to 6 hours).
T37 1379-1456 Sentence denotes Continuous PCR testing has a faster turnaround time (1 u) but a low capacity.
T38 1457-1619 Sentence denotes False negative results in both the very early as well as the late phase of the disease due to low virus shedding at these stages of infection are reported [8–10].
T39 1620-1725 Sentence denotes Studies have shown discrepant results between RT-PCR and chest computed tomography (CT) findings [11,12].
T40 1726-1896 Sentence denotes CT imaging findings in 30 patients with suspicion of COVID-19 pneumonia were shown to have a sensitivity of 97.2% compared to 83.3% of initial nasopharyngeal RT-PCR [13].
T41 1897-2008 Sentence denotes Establishing the diagnosis of COVID-19 is sometimes very challenging and does not only rely on molecular tests.
T42 2009-2171 Sentence denotes We report on two patients who presented at the emergency department with high suspicion of COVID-19 infection based on clinical findings and/or chest-CT findings.
T43 2172-2288 Sentence denotes Nevertheless, SARS-CoV-2 RT-PCR testing was repeatedly negative on repetitive nasopharyngeal, throat and anal swabs.
T44 2289-2400 Sentence denotes Case 1 was a 66 year old male experiencing symptoms of shortness of breath, fever and muscle pain since 8 days.
T45 2401-2450 Sentence denotes Lab findings showed thrombopenia (87,000/µL, ref.
T46 2451-2497 Sentence denotes 149,000–31,9000/µL), lymphopenia (930/µL, ref.
T47 2498-2554 Sentence denotes 1,133–3,105/µL), normal neutrophil count (2,980/µL, ref.
T48 2555-2603 Sentence denotes 1,573–6,100/µL) low eosinophil count (0/µL, ref.
T49 2604-2650 Sentence denotes 28–273/µL), normal basophil count (10/µL, ref.
T50 2651-2765 Sentence denotes 6–50/µL), elevated D-dimers (1,480 ng/mL, ref. <500 ng/mL) and elevated C-reactive protein (29 mg/L, ref <5 mg/L).
T51 2766-2965 Sentence denotes Chest CT on the day of admission showed bilateral ground glass opacities with a crazy paving pattern suspicious for COVID-19 (CT severity score of 10 or CO-RADS classification of 4: COVID-19 likely).
T52 2966-3173 Sentence denotes Repetitive nasopharyngeal swabs on day 8, 9, 12 and 13 as well as anal swabs on day 9 and 13 after symptom onset were all SARS-CoV-2 RT-PCR negative using the protocol described by Corman and colleagues [6].
T53 3174-3305 Sentence denotes Serology on day 13 after symptom onset indicated negative IgM but positive IgG (Prima Professional®, Point-Of-Care antibody Tests).
T54 3306-3437 Sentence denotes On day 13, the patient was admitted to the intensive care unit (ICU) because of type 1 respiratory insufficiency (pO2 60 mmHg, ref.
T55 3438-3470 Sentence denotes 83–108 mm Hg; pCO2 31 mmHg, ref.
T56 3471-3497 Sentence denotes 35–45 mm Hg; pH 7.46, ref.
T57 3498-3509 Sentence denotes 7.35–7.45).
T58 3510-3552 Sentence denotes He did not require mechanical ventilation.
T59 3553-3609 Sentence denotes Based on these findings, he was diagnosed with COVID-19.
T60 3610-3757 Sentence denotes Case 2 was a 14 year old child presenting at the emergency room with 3 days of fever > 39°C, muscle pain, cough, sore throat, headache and fatigue.
T61 3758-3887 Sentence denotes The girl’s father had suffered from fever and respiratory symptoms after contact with multiple COVID-19 patients 4 weeks earlier.
T62 3888-4050 Sentence denotes On day 4 after symptom onset, there was a clinical deterioration to refractory shock and multi-organ failure with hypotension and respiratory and cardiac failure.
T63 4051-4100 Sentence denotes Lab findings showed thrombopenia (89,000/µL, ref.
T64 4101-4147 Sentence denotes 154,000–452,000/µL), lymphopenia (162/µL, ref.
T65 4148-4204 Sentence denotes 1,500–6,500/µL), normal neutrophil count (7,564/µL, ref.
T66 4205-4256 Sentence denotes 2,500–8,000), normal eosinophil count (283/µL, ref.
T67 4257-4300 Sentence denotes 100–500/µL), low basophil count (0/µL, ref.
T68 4301-4415 Sentence denotes 10–100/µL), elevated D-dimers (4,420 ng/mL, ref. <500 ng/mL) and high C-reactive protein (308 mg/L, ref. <5 mg/L).
T69 4416-4463 Sentence denotes Chest CT did not show signs of viral pneumonia.
T70 4464-4526 Sentence denotes Echocardiography revealed decreased left ventricular function.
T71 4527-4597 Sentence denotes She responded well to supportive therapy and corticosteroid treatment.
T72 4598-4691 Sentence denotes Throat swabs on day 3 and 5 after symptom onset were negative for SARS-CoV-2 with RT-PCR [6].
T73 4692-4794 Sentence denotes Serology on day 8 after symptom onset was negative for IgM but positive for IgG (Prima Professional®).
T74 4795-4908 Sentence denotes She was diagnosed with pediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS).
T75 4909-5024 Sentence denotes The case reports mentioned above point out the potential of serological assays to add to the diagnosis of COVID-19.
T76 5025-5130 Sentence denotes So far, a large number of serological assays have been developed in response to the diagnostic need [14].
T77 5131-5247 Sentence denotes Data on the validation and comparison of the performance of these assays are emerging but are still limited [15–18].
T78 5248-5424 Sentence denotes Since antibody production by the specific immune system is subject to delay, a lower diagnostic performance of serological assays in the early phase of the disease is expected.
T79 5425-5543 Sentence denotes So far, studies have revealed that antibodies could be detected as early as 3–6 days after symptom onset [9,10,19,20].