LitCovid-sentences  

PMC:7784786 / 7257-10221 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T66 0-10 Sentence denotes Patient 2:
T67 11-150 Sentence denotes An 89-year old man with a personal history of chronic ischemic cardiopathy, permanent atrial fibrillation, hypertension and hypothyroidism.
T68 151-290 Sentence denotes He has a previous history of alcoholism and several hospital admissions in the last 3 months on account of infectious respiratory diseases.
T69 291-393 Sentence denotes He came to the hospital on 2 April after 7 days of shortness of breath, fever, asthenia and dry cough.
T70 394-492 Sentence denotes He was in contact with a person who returned from a foreign country, where COVID-19 was extending.
T71 493-716 Sentence denotes Physical examination shows signs of respiratory failure characterized by tachycardia, polypnea, intercostal and supraclavicular muscle retraction, high blood pressure, oxygen saturation of 82%, poor diuresis and drowsiness.
T72 717-815 Sentence denotes Chest x-rays showed bilateral pulmonary inflammatory infiltrates, predominantly in the right lung.
T73 816-968 Sentence denotes Admission ECG showed an atrial fibrillation with rapid ventricular response and the initial gasometry showed severe hypoxemia and respiratory alkalosis.
T74 969-1116 Sentence denotes Patient also had leukocytosis, altered globular sedimentation rate as well as elevated values of AST, LDH, D-dimer and positive C-reactive protein.
T75 1117-1188 Sentence denotes He was admitted into the ICU requiring invasive mechanical ventilation.
T76 1189-1286 Sentence denotes Treatment with lopinavir–ritonavir, chloroquine, IFN α-2b, meropenem and linezolid was initiated.
T77 1287-1486 Sentence denotes 3 days after his admission into the ICU, itolizumab was prescribed, due to worsening of the bilateral pulmonary infiltrates together with a deterioration of the ventilatory function (PO2/FiO2 = 173).
T78 1487-1625 Sentence denotes After the first antibody infusion, PO2/FiO2 significantly increased (PO2/FiO2 = 320) and there were evidences of radiological improvement.
T79 1626-1796 Sentence denotes 3 days after, patient showed radiological worsening of the left lung, characterized by alveolar hypoventilation and atelectasis; then, a 70% pneumothorax was established.
T80 1797-1909 Sentence denotes Treatment of the pneumothorax with minimal pleurotomy was very demanding and required 3 days for the resolution.
T81 1910-2104 Sentence denotes The patient received a second infusion of the monoclonal antibody 72 h after the first, while a third dose was administered at the discretion of the treating physicians, 2 days after the second.
T82 2105-2201 Sentence denotes In total, patient received three doses of itolizumab (200 mg) without any related adverse event.
T83 2202-2316 Sentence denotes IL-6 levels were evaluated before itolizumab administration and after 2, 4 and 7 days of the first administration.
T84 2317-2473 Sentence denotes IL-6 was extremely high at baseline (623 pg/ml) and even though cytokine levels reduced roughly 50%, the lowest value remained above 300 pg/ml after 7 days.
T85 2474-2510 Sentence denotes IL-6 kinetics is shown in Figure 2A.
T86 2511-2584 Sentence denotes Apart from IL-6, IL-1 was undetectable at this time point of the disease.
T87 2585-2678 Sentence denotes Interesting, in the case of AST, a significant reduction is detecting at day 7 (pretreatment:
T88 2679-2691 Sentence denotes 156 U/l, D7:
T89 2692-2726 Sentence denotes 40 U/l) as is showed in Figure 2B.
T90 2727-2874 Sentence denotes After 10 days of admission into the ICU, patient presented a myocardial dysfunction and shock that required vasoactive support with norepinephrine.
T91 2875-2964 Sentence denotes On day 13, he finally died, on account of a mixed cardiovascular and respiratory failure.