LitCovid-sentences  

PMC:7784786 / 4325-6380 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T38 0-10 Sentence denotes Patient 1:
T39 11-222 Sentence denotes A 53-year old woman with a personal history of essential hypertension and Type 2 diabetes mellitus presented with symptoms of polypnea of more than 40 rpm, use of respiratory ancillary musculature and dry cough.
T40 223-287 Sentence denotes She arrived from a foreign country where COVID-19 was spreading.
T41 288-419 Sentence denotes Symptoms started on 23 March and COVID-19 was diagnosed on 26 March on the basis of positive real time PCR (RT-PCR) for SARS-CoV-2.
T42 420-576 Sentence denotes Initial gasometry showed moderate hypoxemia and respiratory alkalosis with a partial pressure of oxygen/fraction of inspired oxygen (PO2/FiO2) ratio of 191.
T43 577-638 Sentence denotes Chest x-rays showed interstitial lesions in both lung fields.
T44 639-732 Sentence denotes She started therapy with lopinavir/ritonavir, chloroquine, recombinant IFN α-2b and rocephin.
T45 733-886 Sentence denotes In spite of treatment, the illness subsequently progressed to hypoxemic respiratory failure warranting the initiation of invasive mechanical ventilation.
T46 887-1071 Sentence denotes At day 13 of her admission in the ICU, she showed radiologic worsening of the interstitial multifocal pneumonia, with elevation of ALP, LDH, erythrocyte sedimentation rate and D-dimer.
T47 1072-1127 Sentence denotes Physicians administered itolizumab at a dose of 200 mg.
T48 1128-1256 Sentence denotes After 48 h of the first itolizumab dose, PO2/FiO2 improved and there were evidences of radiological improvement (Figure 1A & B).
T49 1257-1363 Sentence denotes Patient was extubated after the first dose of the antibody and her status changed from critical to severe.
T50 1364-1447 Sentence denotes She received a second dose of the antibody (200 mg), 48 h after the first infusion.
T51 1448-1554 Sentence denotes 3 days after the first administration, patient was hemodynamically stable and has spontaneous ventilation.
T52 1555-1666 Sentence denotes IL-6 levels were evaluated before itolizumab administration and after 2 and 7 days of the first administration.
T53 1667-1756 Sentence denotes IL-6 levels reduced overtime from 172 pg/ml to 60 pg/ml (day 7) as depicted in Figure 2A.
T54 1757-1828 Sentence denotes IL-1 was evaluated at the same time intervals, but it was undetectable.
T55 1829-1998 Sentence denotes In addition, aspartate amino transferase (AST) concentrations were evaluated at different time points showing a reduction from 43 U/l to 24 U/l after 7 days (Figure 2B).
T56 1999-2055 Sentence denotes No adverse events related with itolizumab were reported.