| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T118 |
0-62 |
Sentence |
denotes |
CRS is characterized by high levels of inflammatory cytokines. |
| T119 |
63-145 |
Sentence |
denotes |
Among them, IL-6 is considered a major mediator of this hyperinflammation [18,19]. |
| T120 |
146-254 |
Sentence |
denotes |
Most of the COVID-19 patients-related papers showed the CRS as one of the main hallmark of the disease [20]. |
| T121 |
255-324 |
Sentence |
denotes |
Additionally, IL-6 levels predict severity in COVID-19 patients [21]. |
| T122 |
325-427 |
Sentence |
denotes |
There is high heterogeneity of IL-6 values among papers for classifying severe and nonsevere patients. |
| T123 |
428-575 |
Sentence |
denotes |
In a large meta-analysis of 52 manuscripts, Elshazli and coworkers found that the IL-6 level associated with COVID-19 severity was 22.9 pg/ml [22]. |
| T124 |
576-739 |
Sentence |
denotes |
In a series of patients treated with itolizumab a cutoff of 28 pg/ml discriminates severe patients from nonsevere (manuscript just accepted in Immunity and Aging). |
| T125 |
740-829 |
Sentence |
denotes |
In the present study, the IL-6 concentration of the three patients was above this cutoff. |
| T126 |
830-928 |
Sentence |
denotes |
It confirms the classification of these patients as severe and that the CRS is probably occurring. |
