LitCovid-sentences  

PMC:7784786 / 13157-16527 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T117 0-10 Sentence denotes Discussion
T118 11-73 Sentence denotes CRS is characterized by high levels of inflammatory cytokines.
T119 74-156 Sentence denotes Among them, IL-6 is considered a major mediator of this hyperinflammation [18,19].
T120 157-265 Sentence denotes Most of the COVID-19 patients-related papers showed the CRS as one of the main hallmark of the disease [20].
T121 266-335 Sentence denotes Additionally, IL-6 levels predict severity in COVID-19 patients [21].
T122 336-438 Sentence denotes There is high heterogeneity of IL-6 values among papers for classifying severe and nonsevere patients.
T123 439-586 Sentence denotes In a large meta-analysis of 52 manuscripts, Elshazli and coworkers found that the IL-6 level associated with COVID-19 severity was 22.9 pg/ml [22].
T124 587-750 Sentence denotes In a series of patients treated with itolizumab a cutoff of 28 pg/ml discriminates severe patients from nonsevere (manuscript just accepted in Immunity and Aging).
T125 751-840 Sentence denotes In the present study, the IL-6 concentration of the three patients was above this cutoff.
T126 841-939 Sentence denotes It confirms the classification of these patients as severe and that the CRS is probably occurring.
T127 940-1051 Sentence denotes Several anticytokine therapies have been tried for treating the hyperinflammatory phase of COVID-19 [20,23–25].
T128 1052-1179 Sentence denotes Here, we report the use of a well-known anti-inflammatory antibody targeting CD6 to treat the CRS arising in COVID-19 patients.
T129 1180-1411 Sentence denotes Using an anti-CD6 antibody could reduce the concentration of several pro-inflammatory cytokines, including IL-6, IFN-γ, TNF-α and IL-17, among others, representing an advantage as compared with single-cytokine targeting antibodies.
T130 1412-1537 Sentence denotes The antibody would not exacerbate lymphopenia since it does not induce complement or antibody dependent cytotoxicity [10,11].
T131 1538-1655 Sentence denotes These three SARS-CoV2 patients developed severe respiratory distress together with multifocal interstitial pneumonia.
T132 1656-1760 Sentence denotes Two patients required invasive mechanical ventilation while the third patient only needed oxygen supply.
T133 1761-1946 Sentence denotes They all received the anti-CD6 antibody itolizumab in combination with other drugs incorporated into the Cuban national protocol, including lopinavir/ritonavir, chloroquine and IFNα-2b.
T134 1947-2105 Sentence denotes Regarding to laboratory parameters, AST is strongly associated with mortality risk compared with other parameters, reflecting liver and kidney injury [26,27].
T135 2106-2274 Sentence denotes In our cases, critically ill patients showed a significant reduction of AST concentration after the treatment suggesting an improvement in the function of these organs.
T136 2275-2366 Sentence denotes Itolizumab was very safe and did not seem to exacerbate opportunistic secondary infections.
T137 2367-2492 Sentence denotes Unfortunately, we did no measure neither the frequency nor the total amount of circulating T cells in these initial patients.
T138 2493-2590 Sentence denotes The impact of itolizumab on circulating T cells are being implementing in new recruited patients.
T139 2591-2772 Sentence denotes Our preliminary findings support that IL-6 levels correlated with the severity of the disease and that the antibody was capable of reducing IL-6 concentration in all three subjects.
T140 2773-2852 Sentence denotes One patient died after subsequent respiratory and cardiovascular complications.
T141 2853-2957 Sentence denotes In this particular case, IL-6 concentration was extremely elevated at the moment of itolizumab infusion.
T142 2958-3075 Sentence denotes Although, the levels of IL-6 decreased during treatment, the values at 7 days kept still very high (above 300 pg/ml).
T143 3076-3156 Sentence denotes There was a transient improvement of respiratory function but it was not enough.
T144 3157-3370 Sentence denotes Presumably, the consequences of the hyperinflammatory syndrome (thrombosis, alveolar damage and severe tissue hypoxia) were irreversible at the moment of treatment and patient died as consequence of these factors.