| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-106 |
Sentence |
denotes |
In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease. |
| T4 |
107-200 |
Sentence |
denotes |
Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells. |
| T5 |
201-300 |
Sentence |
denotes |
The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis. |
| T6 |
301-416 |
Sentence |
denotes |
Its effect is associated with the reduction of pro-inflammatory cytokines release, including IFN-γ, IL-6 and TNF-α. |
| T7 |
417-561 |
Sentence |
denotes |
Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access protocol. |
| T8 |
562-632 |
Sentence |
denotes |
Itolizumab was able to reduce IL-6 concentrations in all the patients. |
| T9 |
633-732 |
Sentence |
denotes |
Two of the three patients showed respiratory and radiological improvement and were fully recovered. |
| T10 |
733-887 |
Sentence |
denotes |
We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality. |
