| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T107 |
0-19 |
Sentence |
denotes |
Materials & methods |
| T108 |
20-264 |
Sentence |
denotes |
Three patients with diagnosis of COVID-19 classified as critically ill (two) and severely ill (one) were included in an expanded access trial to receive itolizumab in addition to standard treatment (http://rpcec.sld.cu/trials/RPCEC00000311-En). |
| T109 |
265-399 |
Sentence |
denotes |
The study was approved by a central ethical review board, created especially for COVID-19 and by the Cuban Regulatory Agency (CECMED). |
| T110 |
400-474 |
Sentence |
denotes |
Before the treatment, informed consent was obtained from enrolled patient. |
| T111 |
475-584 |
Sentence |
denotes |
Laboratory results included blood routine, leucocyte subsets and blood biochemical parameters were collected. |
| T112 |
585-865 |
Sentence |
denotes |
The level of inflammatory cytokines was measured using human validated commercially available kit from R&D Systems (MN, USA): human IL-6 Quantikine ELISA Kit (Cat# S6050), human IL-1 beta/IL-1F2 Quantikine ELISA Kit (Cat# SLB50) and human TNF-α Quantikine ELISA Kit (Cat# STA00D). |
| T113 |
866-959 |
Sentence |
denotes |
In the case of IL-6, the normal range of this cytokine in sera is between 0 and 7 pg/ml [17]. |
| T114 |
960-1060 |
Sentence |
denotes |
We used intra-assay precision and inter-assay precision methods to evaluate precision in this study. |
| T115 |
1061-1210 |
Sentence |
denotes |
For intra-assay precision (precision within an assay), three samples of known concentration were tested on one plate to assess intra-assay precision. |
| T116 |
1211-1365 |
Sentence |
denotes |
For inter-assay precision (precision between assays), three samples of known concentration were tested in separate assays to assess inter-assay precision. |
