LitCovid-sentences  

PMC:7781431 / 36508-39179 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T363 0-11 Sentence denotes Conclusions
T364 12-101 Sentence denotes Recently, a new group of molecules, named SPMs that resolve inflammation were elucidated.
T365 102-224 Sentence denotes Further, in efforts to investigate and demonstrate their mechanism of action, their receptors are slowly being discovered.
T366 225-302 Sentence denotes As an additional milestone, SPMs were detected in several biological samples.
T367 303-476 Sentence denotes However, the investigation of the pharmacological principle based on GPCR for SPMs under various physiological and pathological conditions is insufficient (Psychogios et al.
T368 477-495 Sentence denotes 2011; Lukiw et al.
T369 496-502 Sentence denotes 2005).
T370 503-617 Sentence denotes Further research is needed on specific molecular targets of omega-3 fatty acids such as RvE2, RvD2, PDs, and MaRs.
T371 618-892 Sentence denotes The interaction between the host immune system and infectious viral attacks represents new opportunities for the utilization of SPMs. The use of SPMs is likely to help regulate abnormal viral-mediated inflammation and prevent complications such as SARS-CoV-2 cytokine storm.
T372 893-975 Sentence denotes Besides, SPMs play parts in restoring tissue homeostasis, including wound healing.
T373 976-1081 Sentence denotes Therefore, they are very likely to have therapeutic effects against the sequelae of SARS-CoV-2 infection.
T374 1082-1172 Sentence denotes Both inflammation and resolution of inflammation are vital processes of the immune system.
T375 1173-1401 Sentence denotes Therefore, a balance between the need for a sufficient immune response to clear the infection and the rapid decline of immune response to prevent host damage presents a novel opportunity for therapeutic exploitation of the SPMs.
T376 1402-1507 Sentence denotes Further research is needed to identify opportunities to optimize this balance in human viral infectivity.
T377 1508-1687 Sentence denotes Among them, it will be exciting to study how the receptors of SPMs, which act as coreceptors during virus infection, play a role in virus infection and virus-induced inflammation.
T378 1688-1836 Sentence denotes Finally, although not mentioned in this review, the author would like to emphasize that SPMs are effective in treating bacterial infections as well.
T379 1837-2011 Sentence denotes In nutshell, SPMs shows excellent potential as novel therapeutic options for severe inflammation and tissue damage caused by viral infections, including SARS-CoV-2 infection.
T380 2012-2051 Sentence denotes Fig. 1 Inflammation-resolution process.
T381 2052-2141 Sentence denotes Modified from Fullerton and Gilroy (Fullerton and Gilroy 2016), and Lee et al. (Lee 2018)
T382 2142-2174 Sentence denotes Fig. 2 SPMS and their receptors.
T383 2175-2267 Sentence denotes Blue dotted lines mean activation of receptors, and red dotted lines inhibition of receptors
T384 2268-2315 Sentence denotes Fig. 3 Effects of SPMS on the virus life cycle.
T385 2316-2353 Sentence denotes Please refer to the text for details.
T386 2354-2405 Sentence denotes RTA: replication and transcription activator, KSHV:
T387 2406-2445 Sentence denotes Kaposi’s sarcoma-associated herpesvirus
T388 2446-2525 Sentence denotes Fig. 4 Effects of SPMS on the viruses and viral infection-induced inflammation.
T389 2526-2568 Sentence denotes Green lines mean direct antiviral effects.
T390 2569-2671 Sentence denotes Blue dotted lines mean indirect effects on virus and purple dotted lines possible effects (not proved)