| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T20 |
0-272 |
Sentence |
denotes |
Inflammation is an extremely important, self-limiting immune response; however, uncontrolled or unresolved inflammation has been established as a pathophysiological mechanism for various diseases including viral infections, and a cause for prolonged homeostasis imbalance. |
| T21 |
273-514 |
Sentence |
denotes |
Resolution of inflammation occurs in an overlapping stage dominated by the spatial and temporal biosynthesis of pro-resolved mediators (Headland and Norling 2015), SPMs, from essential polyunsaturated fatty acids (PUFAs) during inflammation. |
| T22 |
515-843 |
Sentence |
denotes |
The SPMs initiate the process of resolution which include restriction or cessation of neutrophil infiltration, counter-regulation of chemokines and cytokines, induction of the neutrophils apoptosis and subsequent efferocytosis (the process by which apoptotic cells are removed by phagocytic cells) by macrophages (Reville et al. |
| T23 |
844-1101 |
Sentence |
denotes |
2006), the conversion of macrophages from classically activated (M1) to alternatively activated cells (M2), return of non-apoptotic cells to the vascular system or lymphatic vessels, and the start of the healing process (Fig. 1) (Headland and Norling 2015). |
| T24 |
1102-1185 |
Sentence |
denotes |
These events facilitate proper return homeostasis balance (Serhan and Savill 2005). |
| T25 |
1186-1281 |
Sentence |
denotes |
For a comprehensive review, including structural explanations of SPMs, see reviews (Park et al. |
| T26 |
1282-1322 |
Sentence |
denotes |
2020; Chiang and Serhan 2017; Lee 2012). |
