LitCovid-sentences  

PMC:7781431 / 30047-34443 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T299 0-80 Sentence denotes Respiratory syncytial virus, human immunodeficiency virus, and hepatitis C virus
T300 81-334 Sentence denotes Respiratory syncytial virus (RSV), also known as human respiratory cell fusion virus (HRSV) and human orthopneumovirus, is a virus that causes respiratory infections in which infected mucosal cells fuse to form a syncytium (Schweitzer and Justice 2020).
T301 335-464 Sentence denotes It is the leading cause of lower respiratory tract infections and hospital visits in infancy and childhood (Read and Bosco 2020).
T302 465-635 Sentence denotes RSV infection results in bronchiolitis, which is classically caused by activated macrophages and eventually resolved by alternatively activated macrophages (Shirey et al.
T303 636-642 Sentence denotes 2010).
T304 643-816 Sentence denotes The promotion of these two alternative macrophage fates appears to be related to RSV-induced COX-2 and LXA4 and RvE1-mediated protective measures (Fig. 4) (Richardson et al.
T305 817-836 Sentence denotes 2005; Shirey et al.
T306 837-843 Sentence denotes 2014).
T307 844-1117 Sentence denotes Also, although it does not directly act on the virus, RvD1 inhibits inflammatory signal transduction by polyinosinic-polycytidylic acid, an analogue of RNAs derived from respiratory viruses such as RSV, and the action of RvD1 is mediated by FPR2/ALX and GPR32 (Hsiao et al.
T308 1118-1124 Sentence denotes 2014).
T309 1125-1287 Sentence denotes These reports suggest the critical role of SPMs and lipid mediator class shift in the host’s response to RSV in the initial control and final infection clearance.
T310 1288-1468 Sentence denotes Human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retroviruses) and are classified into two based on the genetic characteristics and viral antigen, HIV-1 and HIV-2.
T311 1469-1585 Sentence denotes HIV infection may progress to acquired immunodeficiency syndrome (AIDS), a progressive failure of the immune system.
T312 1586-1704 Sentence denotes Over time, AIDS causes life-threatening opportunistic infections and a condition in which cancer thrives (Douek et al.
T313 1705-1724 Sentence denotes 2009; Powell et al.
T314 1725-1731 Sentence denotes 2016).
T315 1732-2045 Sentence denotes When co-cultured with HIV-1 infected mononuclear cells and human glial cells (astrocytoma, glial and primary human astrocyte), tumour necrosis factor alpha (TNF-α) and interleukin-1β are produced, and large amounts of LTB4, LTD4, LXA4, and PAF, were also found in media from this co-culture (Fig. 4) (Genis et al.
T316 2046-2052 Sentence denotes 1992).
T317 2053-2163 Sentence denotes So far, this is the only in vitro study to prove, that LXs are produced in direct response to viral infection.
T318 2164-2239 Sentence denotes However, the role of LXs in this infection model has not been investigated.
T319 2240-2465 Sentence denotes Synthetic peptides derived from human immunodeficiency virus type 1 gp120 activate the 7-transmembrane GPCR FPR2/ALX, down-regulating the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes (Deng et al.
T320 2466-2472 Sentence denotes 1999).
T321 2473-2563 Sentence denotes FPR2/ALX acts as an efficient core receptor for the primary isolate of HIV (Shimizu et al.
T322 2564-2570 Sentence denotes 2008).
T323 2571-2681 Sentence denotes Viral entries through the alternative core receptors (CoR) CCR3 and FPR2/ALX depend on the HIV type 1 subtype.
T324 2682-2827 Sentence denotes Viruses pseudotyped with subtype A and C Env proteins use the recently described alternative CoR FPR2 more efficiently than CCR3 (Nedellec et al.
T325 2828-2834 Sentence denotes 2009).
T326 2835-2870 Sentence denotes ChemR23 also acts as a CoR for HIV.
T327 2871-3010 Sentence denotes At this time, HIV-1 and HIV-2 appear to use the N-terminus and the second extracellular loop of ChemR23 during infection (Martensson et al.
T328 3011-3017 Sentence denotes 2006).
T329 3018-3145 Sentence denotes As mentioned above, research is needed to determine the role of SPMs that act as ligands for FPR2 and ChemR23 in HIV infection.
T330 3146-3292 Sentence denotes Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus of the family Flaviviridae with a small (55–65 nm size) envelope (Lee et al.
T331 3293-3299 Sentence denotes 2017).
T332 3300-3454 Sentence denotes The HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphoma in humans (Ferri et al.
T333 3455-3483 Sentence denotes 2015; Rusyn and Lemon 2014).
T334 3484-3564 Sentence denotes To date, there appears to be no report on the effectiveness of SPMs against HCV.
T335 3565-3712 Sentence denotes However, HCV peptide (C5A), an amphiphilic α-helix peptide of HCV, is an activator of the N-formyl peptide receptor in human phagocytes (Lin et al.
T336 3713-3719 Sentence denotes 2011).
T337 3720-3810 Sentence denotes This suggests the possibility of interaction between RvD1 and LXA4, FPR families, and HCV.
T338 3811-3933 Sentence denotes Vitamin D metabolites inhibit HCV and upregulate GPR37 gene expression, which induces cellular autophagy (Gutierrez et al.
T339 3934-3940 Sentence denotes 2014).
T340 3941-4072 Sentence denotes PD1 was recently proposed as a new ligand for GPR37, and some studies suggest a possible relationship between PD1 and HCV (Fig. 4).
T341 4073-4223 Sentence denotes SAA also has antiviral effects against HCV, however, it induces chronic inflammation through FPR2/ALX, causing liver damage (Abouelasrar Salama et al.
T342 4224-4230 Sentence denotes 2019).
T343 4231-4396 Sentence denotes Although research has not been conducted yet, RvD1 and LXA4, which inhibit the action of SAA, are likely to suppress liver damage caused by SAA during HCV infection.