PMC:7781431 / 28687-30045 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T288 0-20 Sentence denotes Herpes simplex virus
T289 21-270 Sentence denotes Herpesviruses 1 and 2 (HSV-1 and HSV-2), with the taxonomic names human alphaherpesvirus 1 and human alphaherpesvirus 2, are the most common causes of human viral infections among the members of the human Herpesviridae family (Chayavichitsilp et al.
T290 271-277 Sentence denotes 2009).
T291 278-617 Sentence denotes Herpes simplex virus (HSV) ocular infection represents another example in which local control of the virus stems from a robust inflammatory response with long-term consequences of chronic inflammation, including the possibility of final blindness due to interstitial keratitis that persists even after the viral infection has been cleared.
T292 618-912 Sentence denotes In animals with HSV, topical administration of RvE1 reduced the influx of CD4+ T cells (both TH1 cells and TH17 cells) and neutrophils, decreased production of inflammatory cytokines including IFNγ and IL-6, and increased levels of the anti-inflammatory cytokine IL-10 (Fig. 4) (Rajasagi et al.
T293 913-919 Sentence denotes 2011).
T294 920-974 Sentence denotes Overall, RvE1 significantly reduced stromal keratitis.
T295 975-1043 Sentence denotes Similar results were demonstrated with PD1 (Fig. 4) (Rajasagi et al.
T296 1044-1050 Sentence denotes 2013).
T297 1051-1351 Sentence denotes Besides, AT-RvD1 treatment significantly reduced the degree of corneal angiogenesis and the severity of stromal keratitis lesions, and AT-RvD1 treated mice had fewer Th1 and Th17 cells in the infected cornea, as well as the reduced number of inflammatory cells, including neutrophils (Rajasagi et al.
T298 1352-1358 Sentence denotes 2017).