LitCovid-sentences  

PMC:7781431 / 22450-24078 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T225 0-37 Sentence denotes Activation of other receptors by SPMs
T226 38-108 Sentence denotes A few studies have reported the possibility of other GPCR involvement.
T227 109-217 Sentence denotes Among them, GPR101 mediates the pro-resolving effects of RvD5n-3 DPA in arthritis and infection (Flak et al.
T228 218-224 Sentence denotes 2020).
T229 225-317 Sentence denotes Besides, SPMs have been reported to activate non-GPCRs receptors, such as nuclear receptors.
T230 318-504 Sentence denotes In a dose-dependent manner, PD1 enhances PPARγ transcriptional activation reporter activity in human neuron-glia (HNG) cells co-transfected with hPPARγ-GAL4 and MH100-tk-Luc (Zhao et al.
T231 505-511 Sentence denotes 2011).
T232 512-629 Sentence denotes This suggests that PD1 is capable of enhancing the peroxisome proliferator-activated receptor gamma (PPARγ) (Fig. 2).
T233 630-728 Sentence denotes The transcriptional activity of PPARγ was significantly increased after treatment with 100 nM PD1.
T234 729-960 Sentence denotes RvD1 was also assumed to be a ligand for PPARγ and inhibited IκBα degradation and NF-κB p65 nuclear translocation in an LPS-induced lung injury model, which was partially reversed by the PPARγ inhibitor GW9662 (Fig. 2) (Liao et al.
T235 961-967 Sentence denotes 2012).
T236 968-1083 Sentence denotes Recently, it has been reported that LXA4 binds to the nuclear aryl hydrocarbon receptor (AhR) (Fig. 2) (Asha et al.
T237 1084-1090 Sentence denotes 2020).
T238 1091-1153 Sentence denotes A GPCR that acts directly on MaR1 has not yet been identified.
T239 1154-1476 Sentence denotes However, MaR1 blocks TRPV1-mediated currents in neurons, acts as a ligand for the retinoid-associated orphan receptor α (RORα), and inhibits TLR4 signalling (Fig. 2) (Park 2015), Chiang et al. found that MaR1 can activate LGR6, a member of the glycoprotein hormone receptor subfamily of rhodopsin-like GPCRs (Chiang et al.
T240 1477-1620 Sentence denotes 2019b), which initiates cAMP, impedance changes, and stimulate an innate immune response against PMNs, monocytes and macrophages (Chiang et al.
T241 1621-1628 Sentence denotes 2019b).