LitCovid-sentences  

PMC:7781431 / 19612-20811 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T195 0-5 Sentence denotes GPR37
T196 6-176 Sentence denotes GPR37 or Parkin-related endothelin-like receptor (Pael-R) was originally discovered through genomic library screening to find new neuropeptide receptors (Marazziti et al.
T197 177-183 Sentence denotes 1997).
T198 184-334 Sentence denotes The GPR37 receptor is primarily expressed in the brain and is associated with neurological disorders such as Parkin’s disease and autism (Lopes et al.
T199 335-341 Sentence denotes 2015).
T200 342-495 Sentence denotes Mutations within GPR37 affect various autism spectrum disorders, regulation of dopamine reuptake and oligodendrocyte differentiation (Fujita-Jimbo et al.
T201 496-518 Sentence denotes 2012; Marazziti et al.
T202 519-536 Sentence denotes 2007; Yang et al.
T203 537-543 Sentence denotes 2016).
T204 544-742 Sentence denotes PD1 is considered as a ligand for GPR37 because it induced a significant increase in intracellular calcium in HEK293 cells overexpressing GPR37 and murine peritoneal-derived macrophages (Bang et al.
T205 743-749 Sentence denotes 2018).
T206 750-982 Sentence denotes Based on the fact that Gpr37-/- mice exhibited increased apoptosis and infarct size, it has recently been suggested that GPR37 is also involved in cell damage protection and inflammation after ischemic stroke (McCrary et al., 2019).
T207 983-1199 Sentence denotes However, due to its clear role in the central nervous system (CNS), the development of a therapeutic agent targeting GPR37 requires a balance between the effect on the central nervous system and therapeutic benefits.