LitCovid-sentences  

PMC:7781431 / 18413-19610 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T181 0-126 Sentence denotes GPR32 is primarily expressed in human PMN, monocytes, adipose tissue and vascular endothelial cells (Sansbury and Spite 2016).
T182 127-355 Sentence denotes RvD1 was identified as a potential agonist due to the activation of GPR32, where [3H]-RvD1 binds to human leukocytes and significantly lowers TNF-α-stimulated NF-κB signalling in GPR32 overexpressing cells (Krishnamoorthy et al.
T183 356-362 Sentence denotes 2010).
T184 363-499 Sentence denotes Although RvD1 has a higher affinity for GPR32 than FPR2/ALX, its interaction with GPR32 has not been extensively studied (Norling et al.
T185 500-506 Sentence denotes 2012).
T186 507-622 Sentence denotes This could be since GPR32 exists as a pseudogene in rodents, which makes animal testing in principle inappropriate.
T187 623-817 Sentence denotes Treatment of inflammatory macrophages expressing GPR32 with RvD1 enhanced the pro-resolving phenotype to increase phagocytosis and decrease the secretion of inflammatory cytokines (Schmid et al.
T188 818-824 Sentence denotes 2016).
T189 825-949 Sentence denotes Also, GPR32 was also involved when during the inhibition of the EMT phenomenon of lung cancer cell lines by RvD1 (Lee et al.
T190 950-956 Sentence denotes 2013).
T191 957-1096 Sentence denotes Additionally, RvD3, AT-RvD3, and RvD5 have all been shown to activate GPR32 in a recombinant system of β-arrestin recruitment (Dalli et al.
T192 1097-1117 Sentence denotes 2013b; Chiang et al.
T193 1118-1124 Sentence denotes 2012).
T194 1125-1197 Sentence denotes These facts suggest the potential redundancy of ligands acting on GPCRs.