LitCovid-sentences  

PMC:7781431 / 15813-17106 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T151 0-53 Sentence denotes N-formyl peptide receptor 2/LX A4 receptor (FPR2/ALX)
T152 54-209 Sentence denotes Originally FPR2 was classified as an FPR receptor due to its activation by the low-affinity endogenous agonist N-formyl methionyl peptide (fMLP) (Ye et al.
T153 210-216 Sentence denotes 1992).
T154 217-455 Sentence denotes The receptor was reclassified as FPR2/ALX, as LXA4 exhibited the highest affinity of all FPR2/ALX endogenous agonists through screening of various receptor ligands using radiolabelled [3H]-LXA4 and subsequent GTPase activity (Fiore et al.
T155 456-474 Sentence denotes 1994; Brink et al.
T156 475-481 Sentence denotes 2003).
T157 482-608 Sentence denotes Binding of LXA4 leads to the stimulation of monocyte chemotaxis, macrophage differentiation, and efferocytosis (Maderna et al.
T158 609-639 Sentence denotes 2010; Maddox and Serhan 1996).
T159 640-764 Sentence denotes LXA4 also reduces the adaptive immune response by reducing memory B cell antibody production and proliferation (Ramon et al.
T160 765-771 Sentence denotes 2014).
T161 772-942 Sentence denotes Endogenous and exogenous lipids, peptides, and proteins have been shown to bind and activate FPR2/ALX to produce inflammatory and anti-inflammatory effects (Takano et al.
T162 943-962 Sentence denotes 1997; Cooray et al.
T163 963-969 Sentence denotes 2013).
T164 970-1129 Sentence denotes Both the LXs and Rvs families, including LXA4, AT-LXA4 (15-epi-LXA4), RvD1, AT-RvD1 (17-epi-RvD1), and Annexin A1 (ANXA1) activate receptors with high potency.
T165 1130-1269 Sentence denotes On the other hand, endogenous antagonists, including serum amyloid A (SAA) and cathelicidin (LL-37) have been identified (Bozinovski et al.
T166 1270-1286 Sentence denotes 2012; Wan et al.
T167 1287-1293 Sentence denotes 2011).