Id |
Subject |
Object |
Predicate |
Lexical cue |
T95 |
0-8 |
Sentence |
denotes |
Maresins |
T96 |
9-213 |
Sentence |
denotes |
Maresins (MaRs) are biosynthesized from DHA by macrophages through the action of 12-LOX, which catalyzes the oxygenation of DHA to 14-hydroperoxidocosahexaenoic acid (14-HpDHA) (Rodriguez and Spur 2020a). |
T97 |
214-346 |
Sentence |
denotes |
This is followed by reduction to 13S, 14S-epoxy-maresin, which is further modified in human macrophages to produce MaR1 (Deng et al. |
T98 |
347-451 |
Sentence |
denotes |
2014) and conversion of 13S, 14S-epoxy-maresin by soluble epoxide hydrolase to produce MaR2 (Deng et al. |
T99 |
452-458 |
Sentence |
denotes |
2014). |
T100 |
459-580 |
Sentence |
denotes |
Maresins, like the many other SPM members mentioned, have anti-inflammatory, protective and healing-promoting properties. |
T101 |
581-829 |
Sentence |
denotes |
In a study using a murine model of respiratory distress syndrome, and initial in vivo production of MaR1was detected during platelet-neutrophil interactions, and its levels increased significantly within 2 hours and peaked at 24 hours (Dalli et al. |
T102 |
830-837 |
Sentence |
denotes |
2013c). |
T103 |
838-961 |
Sentence |
denotes |
Measurement of 17-HDHA in tissue is used as a marker for the level of activation of the MaR production pathway (Wang et al. |
T104 |
962-968 |
Sentence |
denotes |
2015). |
T105 |
969-1146 |
Sentence |
denotes |
Maresin-like lipid mediators MaR-L1 and MaR-L2 are produced by white blood cells and platelets and rescue the reparative function of macrophages damaged by diabetes (Hong et al. |
T106 |
1147-1153 |
Sentence |
denotes |
2014). |
T107 |
1154-1204 |
Sentence |
denotes |
Total synthesis of MaRs has not yet been reported. |