| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T86 |
0-18 |
Sentence |
denotes |
Resolvin Ts (RvTs) |
| T87 |
19-169 |
Sentence |
denotes |
In human platelets, COX-2 pre-treated with aspirin or atorvastatin metabolizes omega-3s, DPA and clupanodonic acid (DPAn-3), to 13S-hydroperoxy forms. |
| T88 |
170-276 |
Sentence |
denotes |
Aspirin and atorvastatin change the activity of COX-2 from cyclooxygenase to hydroperoxide-forming enzyme. |
| T89 |
277-453 |
Sentence |
denotes |
The intermediates formed are transported to the nearby human neutrophils and perhaps by the activity of the ALOX5 enzyme they are metabolized into four polyhydroxy metabolites: |
| T90 |
454-613 |
Sentence |
denotes |
RvT1 (7,13R, 20-trihydroxy-DPAn-3); RvT2 (7, 8,13R-trihydroxy-DPAn-3); RvT3 (7,12,13R-trihydroxy-8Z, 10E, 14E, 16Z, 19Z-DPAn-3); RvT4 (7,13R-dihydroxy-DPAn-3). |
| T91 |
614-763 |
Sentence |
denotes |
These four RvTs are formed by human neutrophils and vascular endothelial cells and are also found in rodents and human infected tissues (Dalli et al. |
| T92 |
764-777 |
Sentence |
denotes |
2013a, 2015). |
| T93 |
778-914 |
Sentence |
denotes |
Recently, the total synthesis of RvT1, RvT2, and its 13R-epimer RvT2, and RvT4 were successfully achieved (Rodriguez and Spur 2020a, b). |
| T94 |
915-1030 |
Sentence |
denotes |
Therefore, it is expected that there will be many physiological and pharmacological research on RvTs in the future. |
