PMC:7780584 / 5805-8788 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T61 0-10 Sentence denotes Discussion
T62 11-126 Sentence denotes COVID-19 is a novel viral illness caused via close contact, respiratory droplets, and aerosolized particles [4, 5].
T63 127-276 Sentence denotes In the review of the current literature, children appear to display milder clinical manifestations for COVID-19 compared to the adult population [6].
T64 277-471 Sentence denotes More recently, SARS-CoV-2 virus infections have been associated with Kawasaki like illness with a hyperimmune state and described as a multisystem inflammatory syndrome of children (MIS-C) [7]. 
T65 472-660 Sentence denotes The Centers for Disease Control and Prevention (CDC) noted that 56% of laboratory-confirmed COVID-19 pediatric cases presented with fever, 54% with cough, and 13% with shortness of breath.
T66 661-785 Sentence denotes Other associated findings are gastrointestinal symptoms, including abdominal discomfort, nausea, vomiting, and diarrhea [8].
T67 786-1031 Sentence denotes Laboratory COVID-19 confirmed pediatric cases can show normal total white blood cell counts with lymphopenia, elevated liver enzymes, lactate dehydrogenase, C-reactive protein, erythrocyte sedimentation rates, and pro-calcitonin levels [9, 10]. 
T68 1032-1131 Sentence denotes Pediatric cases of persistent fever and cheilitis often coincide in children with Kawasaki disease.
T69 1132-1327 Sentence denotes Other associated signs and symptoms are bilateral non-exudative conjunctivitis, cervical lymphadenopathy, mucositis, polymorphous rash, and edema of the hands and feet, all absent in our patient.
T70 1328-1516 Sentence denotes At the time of our literature review, there have been 15 reported cases of atypical, typical, and incomplete Kawasaki like disease in children in the New York State as of April 29th, 2020.
T71 1517-1653 Sentence denotes Over 50% of these patients with MIS-C presented in shock and required blood pressure support, while 33% required mechanical ventilation.
T72 1654-1718 Sentence denotes As of the date of this article, no fatalities were reported [7].
T73 1719-1825 Sentence denotes The exact mechanism of COVID-19 infection and this new multisystem inflammatory syndrome remains unclear. 
T74 1826-2077 Sentence denotes As of April 2020, the World Health Organization (WHO) noted that 80% of confirmed COVID-19 positive pediatric patients displayed mild symptoms such as fever, non-productive cough, and fatigue and often recovered without requiring hospitalization [11].
T75 2078-2177 Sentence denotes This patient presented with fever without an apparent source prompting a partial workup for sepsis.
T76 2178-2269 Sentence denotes The patient required hospitalization for continued diagnostic workup and empiric treatment.
T77 2270-2357 Sentence denotes This patient did not develop any respiratory complications from his COVID-19 infection.
T78 2358-2567 Sentence denotes It is important to now consider COVID-19 as a potential differential diagnosis in addition to routine sepsis workup in pediatric patients presenting with persistent fever without a defined source of infection.
T79 2568-2718 Sentence denotes Occult infectious etiologies such as bacteremia, urinary tract infection, and meningitis, should not be discounted for patients with persistent fever.
T80 2719-2872 Sentence denotes Acute cheilitis may be another manifestation of COVID-19, and the occurrence of this finding in febrile children should raise the suspicion of COVID- 19.
T81 2873-2983 Sentence denotes We suggest testing for COVID-19 for febrile children presenting with cheilitis that is otherwise unexplained.