LitCovid-sentences  

PMC:7755033 / 90486-97364 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T926 0-5 Sentence denotes 3.10.
T927 7-35 Sentence denotes Principle component analysis
T928 36-214 Sentence denotes PCA is one of the most familiar methods of multivariate analysis which attempts to model the total variance of originally formed data set with the unrelated principal components.
T929 215-432 Sentence denotes Absorption rate, TPSA, MW, clog P, NOHNH, NON, number of rotatable bonds and Lipinski’s violations were the various variable properties on which PCA was performed using linear correlation as shown in Figure 6A and 6B.
T930 433-613 Sentence denotes PCA analysis was also performed on leadlikeness (Table 14; Figure 7) as well as for bioactivity score parameters using linear correlation between the variables (Table 13; Figure 8)
T931 614-623 Sentence denotes Figure 6.
T932 625-852 Sentence denotes PCA of physiological properties of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T933 853-862 Sentence denotes Figure 7.
T934 864-1079 Sentence denotes PCA of leadlikeness of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T935 1080-1089 Sentence denotes Figure 8.
T936 1091-1323 Sentence denotes PCA of bioactivity score prediction of WS phytoconstituents versus FDA– approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T937 1324-1333 Sentence denotes Table 15.
T938 1335-1519 Sentence denotes Toxicity risk assessment of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib).
T939 1520-1522 Sentence denotes S.
T940 1523-1526 Sentence denotes No.
T941 1528-1593 Sentence denotes Ligands Mutagenic Tumorigenic Reproductive effective Irritant
T942 1594-1596 Sentence denotes 1.
T943 1598-1634 Sentence denotes Withaferin A None None Mild None
T944 1635-1637 Sentence denotes 2.
T945 1639-1676 Sentence denotes Withanolide A None Mild Mild Mild
T946 1677-1679 Sentence denotes 3.
T947 1681-1718 Sentence denotes Withanolide B None Mild Mild Mild
T948 1719-1721 Sentence denotes 4.
T949 1723-1760 Sentence denotes Withanolide D None None Mild None
T950 1761-1763 Sentence denotes 5.
T951 1765-1802 Sentence denotes Withanolide E None None Mild None
T952 1803-1805 Sentence denotes 6.
T953 1807-1840 Sentence denotes Withanone None Mild Mild Mild
T954 1841-1843 Sentence denotes 7.
T955 1845-1885 Sentence denotes Viscosalactone B None None None None
T956 1886-1888 Sentence denotes 8.
T957 1890-1923 Sentence denotes Anaferine None None None None
T958 1924-1926 Sentence denotes 9.
T959 1928-1964 Sentence denotes Withasomnine None None None None
T960 1965-1968 Sentence denotes 10.
T961 1970-2002 Sentence denotes Losartan None None None None
T962 2003-2006 Sentence denotes 11.
T963 2008-2044 Sentence denotes Procainamide None None None High
T964 2045-2048 Sentence denotes 12.
T965 2050-2084 Sentence denotes Cinacalcet None High None None
T966 2085-2088 Sentence denotes 13.
T967 2090-2121 Sentence denotes Arbidol None None None None
T968 2122-2125 Sentence denotes 14.
T969 2127-2169 Sentence denotes Hydroxychloroquine High None None None
T970 2170-2173 Sentence denotes 15.
T971 2175-2209 Sentence denotes Oberadilol None High None None
T972 2210-2213 Sentence denotes 16.
T973 2215-2428 Sentence denotes Poziotinib High Mild Mild Mild As is evident from Figures 6–8, all WS phytoconstituents fall close in 3D to the standard reference drugs used in the present study, thereby denoting their ‘drug-like’ character.
T974 2429-2583 Sentence denotes Tables 16, 17 and 18 represent the Bravais–Pearson (linear correlation) coefficients of WS phytoconstituents versus FDA-approved standard reference drugs.
T975 2584-2593 Sentence denotes Table 16.
T976 2595-2834 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for physicochemical properties.
T977 2835-2903 Sentence denotes Properties   1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
T978 2904-3030 Sentence denotes % AB 1   –0.719 –0.867 0.387 –0.807 0.0443 –1 0.274 0.99 –0.0259 0.037 –0.0781 0.0966 –0.0537 0.0186 5.38E–05
T979 3031-3159 Sentence denotes (NOHNH) 2 –0.719   0.582 –0.357 0.399 0.243 0.719 –0.466 –0.779 0.214 0.45 –0.346 0.156 0.032 –0.0146 –1.39E–08
T980 3160-3292 Sentence denotes (NON) 3 –0.867 0.582   0.0762 0.938 –0.0124 0.867 0.11 –0.893 –0.397 –0.147 –0.119 –0.00919 –0.0307 0.0873 2.76E–09
T981 3293-3421 Sentence denotes LV 4 0.387 –0.357 0.0762   0.0607 0.182 –0.387 0.76 0.35 –0.822 –0.0907 –0.427 –0.103 –0.00279 –0.0306 1.09E–08
T982 3422-3548 Sentence denotes MW 5 –0.807 0.399 0.938 0.0607   0.012 0.807 0.278 –0.821 –0.491 –0.203 0.157 0.0848 –0.0985 –0.0469 5.89E–10
T983 3549-3678 Sentence denotes RB 6 0.0443 0.243 –0.0124 0.182 0.012   –0.0443 0.363 0.0185 –0.386 0.905 0.157 –0.0754 –0.0364 0.00653 4.45E–09
T984 3679-3807 Sentence denotes TPSA 7 –1 0.719 0.867 –0.387 0.807 –0.0443   –0.274 –0.99 0.0259 –0.0371 0.0782 –0.0964 0.0537 –0.0186 5.38E–05
T985 3808-3936 Sentence denotes clog Pc 8 0.274 –0.466 0.11 0.76 0.278 0.363 –0.274   0.264 –0.931 –0.0242 0.205 0.112 0.0929 0.00734 –1.71E–08
T986 3937-4077 Sentence denotes pc1 9 0.99 –0.779 –0.893 0.35 –0.821 0.0185 –0.99 0.264   9.62E–09 –8.89E–09 5.33E–09 –1.73E–08 6.60E–09 –5.23E–09 1.16E–08
T987 4078-4227 Sentence denotes pc2 10 –0.0259 0.214 –0.397 –0.822 –0.491 –0.386 0.0259 –0.931 9.62E–09   –5.16E–09 –9.75E–09 –1.46E–08 –1.70E–09 3.02E–10 –8.98E–10
T988 4228-4377 Sentence denotes pc3 11 0.037 0.45 –0.147 –0.0907 –0.203 0.905 –0.0371 –0.0242 –8.89E–09 –5.16E–09   1.02E–08 –8.09E–09 –2.00E–09 –2.34E–08 –1.94E–08
T989 4378-4523 Sentence denotes pc4 12 –0.0781 –0.346 –0.119 –0.427 0.157 0.157 0.0782 0.205 5.33E–09 –9.75E–09 1.02E–08   –7.30E–09 9.18E–09 –6.69E–09 5.02E–09
T990 4524-4674 Sentence denotes pc5 13 0.0966 0.156 –0.00919 –0.103 0.0848 –0.0754 –0.0964 0.112 –1.73E–08 –1.46E–08 –8.09E–09 –7.30E–09   4.55E–09 9.35E–09 2.03E–09
T991 4675-4827 Sentence denotes pc6 14 –0.0537 0.032 –0.0307 –0.00279 –0.0985 –0.0364 0.0537 0.0929 6.60E–09 –1.70E–09 –2.00E–09 9.18E–09 4.55E–09   6.33E–09 –1.14E–08
T992 4828-4982 Sentence denotes pc7 15 0.0186 –0.0146 0.0873 –0.0306 –0.0469 0.00653 –0.0186 0.00734 –5.23E–09 3.02E–10 –2.34E–08 –6.69E–09 9.35E–09 6.33E–09   –1.39E–08
T993 4983-5149 Sentence denotes pc8 16 5.38E–05 –1.39E–08 2.76E–09 1.09E–08 5.89E–10 4.45E–09 5.38E–05 –1.71E–08 1.16E–08 –8.98E–10 –1.94E–08 5.02E–09 2.03E–09 –1.14E–08 –1.39E–08  
T994 5150-5159 Sentence denotes Table 17.
T995 5161-5411 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for drug like properties and leadlikeness.
T996 5412-5443 Sentence denotes Properties   1 2 3 4 5 6
T997 5444-5489 Sentence denotes LL 1   –0.669 0.631 0.858 –0.51 –0.066
T998 5490-5543 Sentence denotes clog Pc 2 –0.669   –0.754 –0.912 –0.173 –0.372
T999 5544-5592 Sentence denotes clogS 3 0.631 –0.754   0.896 0.311 –0.316
T1000 5593-5645 Sentence denotes pc1 4 0.858 –0.912 0.896   –1.95E–09 1.70E–09
T1001 5646-5698 Sentence denotes pc2 5 –0.51 –0.173 0.311 –1.95E–09   8.57E–10
T1002 5699-5752 Sentence denotes pc3 6 –0.066 –0.372 –0.316 1.70E–09 8.57E–10  
T1003 5753-5762 Sentence denotes Table 18.
T1004 5764-6005 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for bioactivity score prediction.
T1005 6006-6050 Sentence denotes Properties   1 2 3 4 5 6 7 8 9 10
T1006 6051-6124 Sentence denotes EI 1   0.0219 0.658 0.923 0.689 0.901 0.37 0.114 –0.0254 0.193
T1007 6125-6204 Sentence denotes GPCR 2 0.0219   0.317 –0.0436 0.573 0.354 –0.894 0.229 –0.148 0.0199
T1008 6205-6281 Sentence denotes ICM 3 0.658 0.317   0.543 0.762 0.849 –0.13 –0.501 –0.101 –0.0238
T1009 6282-6358 Sentence denotes NRL 4 0.923 –0.0436 0.543   0.599 0.836 0.456 0.244 –0.106 –0.151
T1010 6359-6434 Sentence denotes PI 5 0.689 0.573 0.762 0.599   0.905 –0.318 0.0426 0.276 –0.0383
T1011 6435-6520 Sentence denotes pc1 6 0.901 0.354 0.849 0.836 0.905   1.08E–09 8.12E–09 –3.79E–09 1.67E–08
T1012 6521-6607 Sentence denotes pc2 7 0.37 –0.894 –0.13 0.456 –0.318 1.08E–09   7.21E–09 1.03E–09 –4.17E–09
T1013 6608-6694 Sentence denotes pc3 8 0.114 0.229 –0.501 0.244 0.0426 8.12E–09 7.21E–09   4.11E–09 3.79E–10
T1014 6695-6785 Sentence denotes pc4 9 –0.0254 –0.148 –0.101 –0.106 0.276 –3.79E–09 1.03E–09 4.11E–09   9.73E–09
T1015 6786-6878 Sentence denotes pc5 10 0.193 0.0199 –0.0238 –0.151 –0.0383 1.67E–08 –4.17E–09 3.79E–10 9.73E–09