LitCovid-sentences  

PMC:7755033 / 71024-72149 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T624 0-122 Sentence denotes On the other hand, withanolide A displayed strong binding to SARS-CoV spike glycoprotein (Table 6; BE: −9.78 kcal/mol, Kd:
T625 123-197 Sentence denotes 67.23 nM), SARS-CoV-2 spike glycoprotein (Table 7; BE: −7.18 kcal/mol, Kd:
T626 198-272 Sentence denotes 5.48 µM), SARS-CoV 3CL-pro main protease (Table 9; BE: –8.93 kcal/mol, Kd:
T627 273-355 Sentence denotes 285.01 nM) and SARS-CoV-2 Nsp10/Nsp-16 complex (Table 11; BE: −10.38 kcal/mol, Kd:
T628 356-366 Sentence denotes 24.67 nM).
T629 367-549 Sentence denotes Interestingly, withanolide A exhibited almost 1000× times stronger binding to SARS-CoV main protease as compared to standard reference drugs arbidol (Table 6; BE: −4.91 kcal/mol, Kd:
T630 550-617 Sentence denotes 251.65 µM) and hydroxychloroquine (Table 6; BE: −5.25 kcal/mol, Kd:
T631 618-629 Sentence denotes 142.18 µM).
T632 630-813 Sentence denotes The same binding profile was observed for withanolide A with respect to SARS-CoV-2 spike glycoprotein as compared to standard reference drugs arbidol (Table 7; BE: −3.14 kcal/mol, Kd:
T633 814-879 Sentence denotes 4.99 mM) and hydroxychloroquine (Table 7; BE: −2.48 kcal/mol, Kd:
T634 880-890 Sentence denotes 15.11 mM).
T635 891-1046 Sentence denotes Withanolide A also displayed a 1000× stronger binding to Nsp-10/Nsp-16 complex from SARS-CoV-2 in comparison to losartan (Table 11; BE: −6.49 kcal/mol, Kd:
T636 1047-1114 Sentence denotes 17.54 µM) and hydroxychloroquine (Table 11; BE: −4.93 kcal/mol, Kd:
T637 1115-1125 Sentence denotes 244.14 µM)